摘要
以辣素功能结构单体N-(4-羟基-3-甲氧基-苄基)-丙烯酰胺(HMBA)为疏水单体,与丙烯酰胺(AM)和2-丙烯酰胺基-2-甲基丙磺酸钠(NaAMPS)通过自由基胶束共聚,制得三元疏水缔合聚合物P(AM-NaAMPSHMBA)(简称PAAH).采用紫外-可见光谱、核磁共振氢谱、热重分析及扫描电子显微镜对共聚物的结构及形貌进行表征,利用原子力显微镜对聚合物水溶液的微观形貌进行观察,并对其溶解性、疏水缔合性、耐温性及抑菌性能进行了研究.结果表明,所得共聚物中疏水单体含量与投料比基本一致;PAAH具有良好的速溶性,当聚合物浓度超过一定值后,溶液黏度急剧增加,且随着疏水单体含量增加,疏水缔合性能增强;原子力显微镜观察证实了聚合物水溶液中网络结构的存在.与未改性的P(AM-NaAMPS)(简称PAA)共聚物相比,引入具有生物活性且带有刚性苯环结构的HMBA单体可使PAAH共聚物热稳定性增强,耐温性能提高,并赋予其优良的抑菌性能.
A series of hydrophobiCally associating PAAH [ P （AM-NaAMPS-HMBA） ] copolymers was pre- pared through micellar copolymerization with acrylamide （AM） and 2-acrylamide-2-methylpropane sulphonate （NaAMPS） as hydrophilic comonomers and capsaicin-like N-（ d-hydroxy-3-methoxy-benzyl ） acrylamide （HMBA） as the hydrophobic comonomer. The structures of PAAHs were identified by UV-Vis, 1H NMR and SEM. The TGA and AFM were employed to study the thermal stability and the morphology of PAAH aqueous solution. The solution behavior was examined with respect to copolymer concentration, hydrophobe content and temperature. Also, the solubility property and antibacterial activity were investigated. The results show that the content of hydrophobic comonomer in PAAHs coincides approximately with its feed ratio. PAAH exhibits instant solubility and the solution viscosity increases sharply when the polymer concentration surpasses critical associating concentration（ c＊ ）. Observations from AFM confirmed the existence of associative structures in PAAH aqueous solution and the intermolecular hydrophobic association is enhanced as hydrophobe content in- creases. Compared with unmodified PAA, incorporation of HMBA greatly improves the thermal stability of PAAH. Moreover, PAAH is endowed with considerable antibacterial activity against Escherichia coli and Staphylococcus aureus.
出处
《高等学校化学学报》
SCIE
EI
CAS
CSCD
北大核心
2013年第12期2887-2895,共9页
Chemical Journal of Chinese Universities
基金
国家自然科学基金(批准号:51102219)
国家'八六三'计划项目(批准号:2010AA065104)
国家科技支撑计划项目(批准号:2012BAB15B02)资助
关键词
疏水缔合
辣素
溶解性
热稳定性
抑菌性
Hydrophobically associating
Capsaicin
Solubility property
Thermal stability
Antibacterialactivity
