摘要
目的:对肝脏神经内分泌肿瘤进行病理学分级,探讨其临床病理特点和预后.方法:收集34例肝脏神经内分泌肿瘤,分为原发组和转移组,应用免疫组织化学方法及透射电镜技术对肿瘤进行观察,结合文献分析肿瘤的临床病理学特点.结果:原发组神经内分泌瘤NET1级(G1级)1例,神经内分泌瘤NET2级(G2)1例,神经内分泌癌NEC(G3)2例;转移组NET1级(G1级)3例,NET2级(G2)15例,NEC(G3)12例.结论:肝脏神经内分泌肿瘤分为原发性神经内分泌肿瘤和转移性神经内分泌肿瘤,肝脏原发性神经内分泌肿瘤非常罕见,需要完全排除转移性的肝脏神经内分泌肿瘤才能诊断为肝脏原发性神经内分泌肿瘤.手术是治疗肝脏神经内分泌肿瘤的有效手段.
AIM： To investigate the pathological classifica- tion, clinicopathological characteristics and prognosis of hepatic neuroendocrine tumors. METHODS： Thirty-four cases of hepatic neuro- endocrine tumors were divided into an primary disease group and a metastatic disease group. Hepatic neuroendocrine tumors were studied by immunohistochemistry and electron microsco- py, and their clinicopathological characteristics were analyzed. RESULTS： Hepatic neuroendocrine tumors could be divided into three groups： neuroendocrine tumor （G1）, neuroendocrine tumor （G2） and neu- roendocrine carcinoma （G3）. There were I case of neuroendocrine tumor （G1）, 1 case of neuroendo- crine tumor （G2） and 2 cases of neuroendocrine carcinoma （G3） in the primary disease group, and the corresponding figures in the metastatic dis- ease group were 3, 15 and 12, respectively. CONCLUSION： Primary hepatic neuroendocrine tumors are very rare. The diagnosis of primaryhepatic neuroendocrine tumors must eliminate the possibility of metastatic hepatic neuroendo- crine tumors. Surgery is an effective treatment modality for hepatic neuroendocrine tumors.
出处
《世界华人消化杂志》
CAS
北大核心
2013年第33期3631-3637,共7页
World Chinese Journal of Digestology
关键词
肝肿瘤
神经内分泌肿瘤
免疫组织化学
Hepatic tumors
Neuroendocrine tu-mors
Immunohistochemistry
