摘要
目的探讨白细胞介素-6(IL-6)、超敏C反应蛋白(hs-CRP)、α1酸性糖蛋白(α1-AG)在慢性阻塞性肺病急性加重期(AECOPD)老年患者血清中的表达变化和临床价值。方法运用ELISA法检测40例老年AECOPD患者治疗前后血清IL-6、hs-CRP、α1-AG含量,并与30例正常老年人比较,分析3个指标与AECOPD的关系。结果 COPD急性加重期IL-6、hs-CRP、α1-AG均高于缓解期,有显著性差异(P<0.01),实验组无论是加重期还是缓解期IL-6、hs-CRP、α1-AG均高于对照组,有显著性差异(P<0.01)。实验组加重期及缓解期3个指标两两比较均呈正相关性(P<0.05)。结论 IL-6、hs-CRP、α1-AG参与了老年COPD急性加重期的过程,3个指标对AECOPD早期诊断、治疗疗效评估有重要参考价值。
Objective To explore the expression and clinical value of serum interleukin -6 （IL-6） ,high sensitive C re- active protein （hs-CRP）,alpha 1 acid glycoprotein （α1-AG） in elderly patients with acute exacerbation of chronic obstructive pulmonary disease （AECOPD）. Methods Used ELISA to detect serum IL-6,hs-CRP,α1-AG in 40 elderly patients with a- cute exacerbation of COPD before and after treatment,compared with 30 healthy elderly patients, and analysed the relationship between the three indexes and AECOPD. Results The level of IL-6,hs-CRP,α1-AG in acute exacerbation of COPD were significantly higher than those in remission period. IL-6,hs-CRP,α1-AG levels of the experimental group were significantly higher than those in the control group in both exacerbation and remission. It was positive correlation between the three indexes in both the exacerbation of COPD and remission of COPD. Conclusion IL-6,hs-CRP and α1-AG participate the process of a- cute exacerbations of COPD, play an important role in diagnosing AECOPD in early stage and curative effect evaluation.
出处
《中国现代医药杂志》
2013年第11期17-19,共3页
Modern Medicine Journal of China
