摘要
利用气象环境模拟箱模拟一次南京市2001年7月热浪的温度变化过程。给予ApoE-/-小鼠热刺激,以此探讨热浪过程对小鼠SOD的影响。将18只雄性ApoE-/-小鼠分为对照组、热浪组、热浪BH4组,并将2实验组放入气候箱,每日测量小鼠体重、肛温,给BH4组小鼠灌胃,并于模拟结束后采集心脏组织液测量SOD活力。结果发现,热浪组小鼠与对照组、热浪BH4组小鼠相比,肛温有明显上升(P<0.01),心脏SOD活力显著下降(P<0.01);BH4组与对照组间差异不具有统计学意义,各组小鼠体重变化不大。可见,热浪后心脏SOD活性下降,可能引起机体氧化损伤、脂质代谢紊乱,形成动脉粥样硬化,SOD系统可能是一个重要的内源性抑制冠心病发生机制。BH4有提高身体散热效率及缓解热浪对SOD影响的作用,可减少高温热浪天气的危害。
18 male ApoE-/- mice were divided into the control, heat wave, BH4 group respectively to explore the effects of temperature rising process in heatwaves on SOD in ApoE-/- mice. The groups of heat wave and BH4 were exposed to the simulated heatwave process which is collected from Nanjing City in July of 2001. The body weight and rectal temperature of every mouse were measured every day. Cardiac tissue fluids were collected for SOD activity measurement after the end of the simulation. Compared with the control and BH4 groups, mice＇ rectal temperature of the heat wave group increased while the activity of SOD decreased significantly（ P 〈0. 01 ）. No significant difference was found between the control group and BH4 group while weight in all groups had no significant change SOD activity in heart decreased after heat wave. It could cause oxidative damages and lipid metabolism disorders which may lead to the formation of atheroselerosis. So the SOD system may be an important endogenous inhibitory mechanism of coronary heart disease. BH4 can improve the cooling efficiency and SOD activity in the body so that it may reduce the hazards caused by heatwave weather.
出处
《科学技术与工程》
北大核心
2013年第35期10600-10603,共4页
Science Technology and Engineering
基金
国家公益行业专项(GYHY201106034)资助
关键词
热浪
超氧化物歧化酶
冠心病
四氢生物蝶呤
heat wave superoxide dismutase coronary heart disease tetrahydrobiopterin
