摘要
目的观察维生素B5(泛酸)对全饥饿大鼠脑脂质过氧化产物丙二醛(MDA)、还原型谷胱甘肽(GSH)、谷胱甘肽过氧化物酶(GSH-Px)、超氧化物歧化酶(SOD)的动态变化及保护作用。方法以饥饿昆明大鼠为模型,灌胃补充维生素B5,观察大鼠饥饿后不同时期脑MDA、GSH、GSH-Px及SOD的变化。结果饥饿后大鼠脑MDA含量明显升高,补充维生素B5后大鼠脑组织MDA含量在禁食4d与7d较饥饿前无明显升高,与全饥饿对照组比较差异有统计学意义。维生素B5对饥饿大鼠脑SOD,GSH-Px活力无影响,但显著提高GSH水平。结论维生素B5能减轻饥饿对大鼠脑组织氧化应激反应。
Objective To study the effect of vitamin Bs on lipid peroxidation in starved rats＇ brain. Methods To inject vitamin Bs intragastricly to starved rats, then to examine brain MDA, GSH content and the activity of GSH-Px and SOD at different fasting period. Results The level of MDA was significantly increased in rat＇s brain after starvation. Upon vitamin B5 treatment, there was no obvious increase of MDA between normal rats and rats starved for 5 days or 7 days. However, when compared to the starved group, there was significant decrease after vitamin Bs treatment. Moreover, vitamin Bs had no effect on the activity of SOD and GSH-Px in starved rat＇s brain, but it could enhance the level of GSH. Conclusion Vitamin Bs can protect rats from harmful lipid peroxida- tion and some of the mechanisms were probably due to enhancing the level of GSH.
出处
《山西医药杂志（上半月）》
CAS
2013年第12期1335-1337,共3页
Shanxi Medical Journal
基金
国家自然科学基金(81370084)
