期刊文献+

宏基因组的生物信息分析 被引量:5

Bioinformatics analysis on metagenome
在线阅读 下载PDF
导出
摘要 基于高通量测序的宏基因组学研究是近年来的研究热点之一。宏基因组的生物信息分析正在逐渐完善成熟,各种分析软件和流程的开发与应用,极大地促进了宏基因组研究的发展,特别是在遗传与进化、基因发现、宏基因组和人类疾病的相关研究等方面取得了显著成果。本文旨在结合宏基因组学的研究内容和研究方向,对宏基因组的生物信息分析方法进行综述,探讨宏基因组的生物信息分析面临的机遇和挑战。 Utilizing the service provided by next generation sequencing, metagenomics has become one of the hotspots in current research. Following the progress on software development and analyzing platform, significant achievements had been made in genetics, gene finding, microbial communities and human disease investigation, and so on. This mini review aims to address the progress in bioinformatics analysis regarding metagenomics research, discuss the opportunities and challenges of modern metagenomies from a bioinformatics perspective.
出处 《生物信息学》 2013年第4期282-286,共5页 Chinese Journal of Bioinformatics
基金 北京市科学技术研究院海外人才专项资助(0TP-2012-001)
关键词 宏基因组 生物信息学 高通量测序 Metagenome Bioinformatics High Throughput Sequencing
  • 相关文献

参考文献30

  • 1Chen K,Pachter L. Bioinformatics for Whole-genome Shotgun Sequencing of Microbial Communities[J].{H}PLoS Computational Biology,2005,(02):106-112.
  • 2Cole JR,Wang Q,Cardenas E,Fish J Chai B Farris RJ Kulam-Syed-Mohideen AS McGarrell DM Marsh T Garrity GM Tiedje JM. The Ribosomal Database Project:Improved Alignments and New Tools for rRNA Analysis[J].{H}Nucleic Acids Research,2009,(suppl 1):D141-D145.
  • 3Lev RE,Turnbaugh PJ,Klein S,Gordon JI. Microbial Ecology:Human Gut Microbes Associated with Obesity[J].{H}NATURE,2006,(7122):1022-1023.
  • 4Huber JA,Mark Welch DB,Morrison HG,Huse SM,Neal PR,Butterfield DA,Sogin ML. Microbial Population Structures in The Deep Marine Biosphere[J].{H}SCIENCE,2007,(5847):97-100.
  • 5Ley RE,Hamady M,Lozupone C,Turnbaugh P J Ramey RR Bircher JS Schlegel ML Tucker TA Schrenzel MD Knight R Gordon JI. Evolution of Mammals and Their Gut Microbes[J].{H}SCIENCE,2008,(5883):1647-1651.doi:10.1126/science.1155725.
  • 6Bartram AK,Lynch MD,Stearns JC,Moreno-Hagelsieb G,Neufeld JD. Generation of Multimillion-sequence 16s rrna Gene Libraries From Complex Microbial Communities by Assembling Paired-End Illumina Reads[J].{H}APPLIED AND ENVIRONMENTAL MICROBIOLOGY,2011,(11):3846-3852.
  • 7Mitreva M. Structure,Function and Diversity of the Healthy Human Microbiome[J].{H}NATURE,2012.207-214.
  • 8Diehl GE,Longman RS,Zhang JX,Breart B Galan C Cuesta A Schwab SR Littman DR. Microbiota Restricts Trafficking of Bacteria to Mesenteric Lymph Nodes by CX (3) CR 1 (hi) Cells[J].{H}NATURE,2013,(7435):116-120.
  • 9Rondon MR,August PR,Bettermann AD,Brady SF Grossman TH Liles MR Loiacono KA Lynch BA MacNeil IA Minor C Tiong CL Gilman M Osburne MS Clardy J Handelsman J Goodman RM. Cloning the Soil Metagenome:A Strategy for Accessing the Genetic and Functional Diversity of Uncultured Microorganisms[J].{H}APPLIED AND ENVIRONMENTAL MICROBIOLOGY,2000,(06):2541-2547.
  • 10Mardis E R. Next-Generation DNA Sequencing Methods[J].{H}Annual Review of Genomics and Human Genetics,2008.387-402.

同被引文献50

引证文献5

二级引证文献13

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部