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钙离子钙调蛋白激酶Ⅱ-组蛋白去乙酰化酶信号通路与心肌肥厚的研究进展 被引量：3

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摘要 心肌肥厚最初是维持正常心功能的一种补偿机制，也是心脏疾病发病率和致死率较高的主要危险因素。很多动物心肌肥厚和心力衰竭时发生钙离子钙调蛋白激酶Ⅱ-（CaMKⅡ）磷酸化增加和活性提高。CaMKII主要通过激酶的活性作用于下游信号分子，从而改变细胞核内基因转录，在心肌肥厚的信号转导中发挥重要作用。
作者 殷培培 吴剑 龚惠 邹云增
机构地区 复旦大学生物医学研究院 复旦大学附属中山医院
出处 《上海医学》 CAS CSCD 北大核心 2013年第11期976-979,共4页 Shanghai Medical Journal
关键词 钙调蛋白激酶Ⅱ 心肌肥厚 组蛋白去乙酰化酶 钙离子 信号通路 CAMKII 活性作用 疾病发病率
分类号 R541 [医药卫生—心血管疾病]
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参考文献31

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二级参考文献16

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上海医学
2013年 第11期

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