摘要
建立了氯甲酸异丁酯质量内控方法。实验采用毛细管气相内标法含量测定方法,用HP-5（30 m×0.32 mm×0.25μm）毛细管气相色谱柱,FID检测器,以正辛烷为内标进行氯甲酸异丁酯测定。氯甲酸异丁酯在0.30~0.49μg/μL（r=0.999 9）范围内呈良好线性关系;氯甲酸异丁酯回收率为96.55%。采用滴定方法测定其游离酸含量。
A method for the content determination of isobutyl chloroformate was established by using capillary gas chromatography with a HP-5（30 m×0.32 mm×0.25 μm）capillary column and a flame ionization detector. Octane was used as the internal standard substance. The linear range of isobutyl chloroformate was 0.30 ~ 0.49 μg / μL（r=0.9999）and its recovery was 96.55%. Free acid was measured by titration.
出处
《精细化工中间体》
CAS
2013年第5期77-80,共4页
Fine Chemical Intermediates
基金
"十二五"国家重大新药创制科技重大专项(2011ZX09102-009-002)
贵州省中药现代化科技产业研究开发专项(黔科合中药字[2012]5054)
贵州省创新人才基地(黔人领发[2011]1号)
