摘要
目的多因素造模方法建立COPD合并抑郁障碍大鼠模型。方法采用两次气管滴入脂多糖、烟熏及不可预测性应激刺激建立大鼠模型。结果模型大鼠一般表征、行为学表现、肺功能、病理学改变及5-HT水平符合COPD合并抑郁障碍的表现。结论模型与人类COPD合并抑郁障碍病程发展及临床特征较为接近,此方法建立的COPD合并抑郁障碍动物模型是可行的。
Objective To establish the model of rats with chronic obstructive pulmonat3, disease complicated with depression disorder by multiple factors method. Methods The model rats were established by twice tracheal in- stillation of lipopolysaceharide, smoking and unpredictable stimulating. Results The rat model of general character- ization, behavior, pulmonary function, pathological changes and the level of 5-HT were in accordance with COPD complicated with depression disorder. Conclusion The clinical features and development course of COPD rats com- plicated with depression disorder is close to the features of COPD patients complicated depression disorder, therefore, animal model set by this method is feasible.
出处
《临床肺科杂志》
2014年第1期4-6,共3页
Journal of Clinical Pulmonary Medicine
基金
国家自然科学基金(No 81202808)
关键词
慢性阻塞性肺疾病
抑郁障碍
大鼠模型
chronic obstructive pulmonary disease
depression
rat mode!
