摘要
以2-氨基-3-羟基吡啶为原料，固体光气为环化剂合成了甲基吡啶磷杀虫剂重要中间体嗯唑[4，5-b]吡啶-2（3H）酮。考察了溶剂种类、溶剂用量、物料配比对反应的影响。优化的工艺条件为：33g2-氨基-3-羟基吡啶，以70mL吡啶为溶剂，n（光气）：凡（2-氨基-3-羟基吡啶）：1．1：1，反应温度为60～70℃。优化条件下产品收率达84．31％。
Oxazolo L 4,5-b J pyridine-2 （3H）-one was prepared from 2-amino-3-hydroxypyridine via cyclization with bis （trich｜oromethyl）carbonate. The effects of different solvents,solvent amount and reactants ratio on the reaction were investigated. The optimal conditions were as follows：the solvent amount of pyridine of 70 mL,the molar ratio of phosgene to 2-amino-3-hydroxypyridine of 1.1 to 1, reaction temperature of 60~70~C. The yield of product was 84.31%.
出处
《精细化工中间体》
CAS
2013年第6期20-21,32,共3页
Fine Chemical Intermediates
