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HER-2/neu癌基因与肿瘤的生成及演进 被引量:1

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摘要 HER- 2 / neu癌基因产物是 185 k D的具酪氨酸蛋白激酶活性的待定生长因子受体 ,属 EGFR家族。 HER- 2在乳腺癌、NSC、L C卵巢癌、胃癌、结直肠癌中扩增并过量表达 ,与药物抗性及不良预后有关。本文综述了 HER- 2癌基因与乳腺癌、卵巢癌的生成及演进关系研究进展。HER- 2癌基因可能是 WTP5 3、WTPRb基因作用的靶子 ,其生瘤作用与其对凋亡的抑制。
作者 王志洁
出处 《国外医学(遗传学分册)》 2000年第6期294-297,共4页 Foreign Medical Sciences(Section of Genetics )
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  • 1劳埃德尔 D,古生物学报,1990年,29卷,3期,331页
  • 2赵裕亭,地质学报,1984年,2期,97页
  • 3陈旭,中国科学院南京地质古生物研究所集刊,1978年,12卷,1页
  • 4团体著者,西南古生物图册.贵州分册.1,1978年,685页
  • 5团体著者,西南古生物图册.四川分册.1,1978年,485页
  • 6穆恩之,西南地区地层古生物手册,1974年,219页

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  • 1Veronesi U, Cascinelli N, Mariani L, et al. Twenty-year followup of a randomized study comparing breast-conserving surgery with radical mastectomy for early breast cancer [J]. N Engl J Med,2002, 347(16): 1227~1232
  • 2Arriagada R, Le MG, Contesso G, et al. Predictive factors for local recurrence in 2006 patients with surgically resected small breast cancer[J]. Ann Oncol, 2002, 13(9): 1404 -1413
  • 3Jhingran A, Kim JS, Buchholz TA, et al. Age as a predictor of outcome for women with DCIS treated with breast-conserving surgery and radiation: The University of Texas M.D. Anderson Cancer Center experience [J]. IntJ Radiat Oncoi Biol Phys, 2002,54(3): 80
  • 4Park CC, Mitsumori M, Nixon A, et al. Outcome at 8 years after breast -conserving surgery and radiation therapy for invasive breast cancer: influence of margin status and systemic therapy on local recurrence[J].J Clin Oncol, 2000, 18(8): 1668~1675
  • 5Elkhuizen PH, Hermans J, Leer JW, et al. Isolated late local recurrences with high mitotic count and early local recurrences following breast-conserving therapy are associated with increased risk on distant metastasis [J]. Int J Radiat Oncol Biol Phys, 20
  • 6Fodor J, Major T, Polgar C, et al. The impact of radiotherapy on the incidence and time of occurrence of local recurrence in earlystage breastcancer after breast conserving therapy [J]. Neoplasm,2000, 47(3): 181~186
  • 7Chang J, Clark GM, Allred DC, et al. Survival of patients with metastatic breast carcinoma: importance of prognostic markers of the primary tumor[J]. Cancer, 2003, 97(3): 545-553
  • 8Haffty BG, Brown F, Carter D, et al. Evaluation of HER-2 neu oncoprotein expression as a prognostic indicator of local recurrence in conservatively treated breast cancer: a case-control study[J]. Int J Radiat Oncol Biol Phys,1996, 35(4): 751~757
  • 9Molina R, Jo J, Zanon G, et al. Utility of C-erbB-2 in tissue and in serum in the early diagnosis of recurrence in breast cancer patients: comparison with carcinoembryonic antigen and CA15.3[J].Br J Cancer, 1996, 74(7): 1126~1131
  • 10Ziyaie D, Hupp TR, Thompson AM. P53 and breast cancer[J].Breast, 2000, 9(5): 239-246

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