摘要
目的观察紫杉醇联合顺铂(TP方案)和吉西他滨联合顺铂(GP方案)对临床III期、IV期非小细胞肺癌(NSCLC)的疗效和安全性。方法 47例晚期NSCLC患者随机分成2组分别接受TP方案和GP方案进行全身化疗2个周期以上,其中Ⅲ期NSCLC患者30例,占63.8%,lV期NSCLC患者17例,占36.2%。结果 TP和GP总的有效率分别为42.8%和40.5%,入组患者的不良反应都在可控制的范围。结论紫衫醇联合顺铂方案和吉西他滨联合顺铂方案均对临床III期、IV期非小细胞肺癌安全有效,均可作晚期非小细胞肺癌一线化疗方案。
Objective To evaluate the efficacy and toxic reaction of TP and GP on III stages and IV stages non-small cell lung cancer （NSCLC）. Methods A total of 47 patients with advanced NSCLC were randomized into two groups, which included 30 cases （63.8%）in stageⅢ and 17 patienees（36.2%）in stage IV. All the patients had accepted the intravenous chemotherapy of TP or GP for 2 cycles at least. Reaulta The total effective rate of TP and GP for advanced NSCLC were 42.8% in TP group and 40.5% in GP group. The adverse effects of two regiments were little and tolerable. Conclusion Regiments of TP and GP an safe and effective meth- ods in the treatment of advanced stage NSCLC. They could be the first regiment of chemotherapy in III stages and IV stages NSCLC.
出处
《山西大同大学学报（自然科学版）》
2013年第6期46-48,共3页
Journal of Shanxi Datong University(Natural Science Edition)
