摘要
目的:观察益气活血法四妙通脉汤防治大鼠下肢DVT疗效。方法:SD大鼠80只,随机分为4组。A组20只,造模后四妙通脉汤灌胃给药;B组20只,造模后每日肌肉注射低分子肝素钠;C组20只,只结扎,不给药;D组20只,开腹后不结扎,不给药。结果:四妙通脉汤能减轻大鼠下肢肿痛,改善大鼠的一般状态。用药7d,A、B、C组D-D和PT时间均下降,A、B两组与C组比较差异有统计学意义(P<0.01),A、B两组之间比较差异无统计学意义(P>0.05);A组电镜下仅1只为不完全性血栓,血栓发生率5%;B组电镜下1只静脉为完全性血栓,发生率5%;C组15只为完全性血栓,5只为不完全性血栓,血栓发生率100%;D组20只,静脉无血栓。结论:益气活血方药四妙通脉汤对深静脉血栓的防治有较好疗效,能改善下肢肿痛,具有抗凝聚、提高纤溶活性的作用。
Objective： To observe the effect of supplementing qi and activating blood formula Simiaotongmai Decoction in treating lower extremity deep vein thrombosis （DVT） of rats. Methods： Eighty SD rats were randomly divided into four groups, twenty in each group. Group A received intragastric administration 6 hours after operation, group B received intra- muscular injection of heparin sodium once daily, group C only received ligation with no administration, and group D re- ceived neither ligation nor administration. Results：Simiaotongmai Decoction reduced lower extremity swelling of DVT rats and improved the general state. After 7--day treatment, D--dimer and PT time in group A, B, and C all decreased than before treatment. There was significant difference between group A, B and group C （P〈0.01）, but no significant differ- ence was found between group A and group B （P〉0.05）. Electron microscope showed one case of incomplete thrombosis in group A （5% incidence）, one ease of complete thrombosis in group B （5% incidence）, 15 complete thrombosis and 5 in- complete thrombosis in group C （100% incidence）. There was no thrombosis in group D. Concluslon：Supplementing qi and activating blood formula Simiaotongmai Decoction used in the prevention and treatment of deep vein thrombosis can reach a good effect and improve lower extremity swelling through the function of anti-coagulation and enhancing the role of fibrino- lytic activity.
出处
《中国中医骨伤科杂志》
CAS
2014年第1期5-7,共3页
Chinese Journal of Traditional Medical Traumatology & Orthopedics
基金
青岛市经济技术开发区科技局科技三项经费资助
关键词
四妙通脉汤
益气活血法
大鼠
深静脉血栓
SimiaoTongmai decoction
Supplementing qi and activating blood circulation
Rats
Deep venous thrombosis
