摘要
目的探讨白介素-6(IL-6)和肿瘤坏死因子-α(TNF-α)在有遗传史的原发性高血压(EH)子代中的作用及临床意义。方法用ELISA方法检测有EH遗传史的患者及其子代和正常人群及其子代血清IL-6、TNF-α水平,并将二者进行比较。结果①高血压患者比正常人群血清IL-6、TNF-α明显升高(P<0.01),②有高血压遗传史的子代和正常人群的子代相比,前者血清IL-6、TNF-α高于后者(P<0.05)。结论高血压患者血清IL-6、TNF-α升高,而在他们血压正常的子代中也增高,提示:高血压可引起机体内血清IL-6、TNF-α水平升高,从而参与和促进了高血压的发展,这种高的IL-6、TNF-α水平可能与遗传有关。
Objective To discuss the clinical significance of offspring serum in IL - 6 and TNF-α of EH with genetic history. Methods The IL- 6 and TNF-α were detected on EH patients with genet- ic history and their offspring and those of normal people and their offspring by ELISA. Results Compared with normal people, EH patients had much clearer increase in IL- 6 and TNF-α（P〈0.01）. Compared with offspring of normal people, offspring of EH patient with genetic history had much higher IL- 6 and TNF-α（P〈0.05）. Conclusions EH patients have an increased in IL- 6 and TNF -α, while their offspring with normal hypertension have an increased in IL- 6 and TNF-α as well, which can be indicated that EH is responsible for the increase of IL - 6 and TNF -α and get involved and increase the development of EH. The high level of IL- 6 and TNF-α can be related to genetic factors.
出处
《中国煤炭工业医学杂志》
2014年第1期1-3,共3页
Chinese Journal of Coal Industry Medicine
基金
河北省科技厅课题基金(项目编号:12276104D-52)
