摘要
目的 :探讨血管紧张素转换酶抑制剂对凝血及纤溶系统的影响。方法 :急性冠状动脉综合征患者 48例 ,随机分为对照组 (1 6例 )和苯那普利组 (32例 ) ,对照组按临床常规处理 ,苯那普利组在此基础上加用苯那普利 1 0 mg/ d,分别于入院后即刻和第 3天采血测激活的凝血时间(ACT)和血浆组织型纤溶酶原激活剂 (t- PA)及其抑制物 (PAI- I)。结果 :治疗前后及组间比较ACT均无显著变化 ;两组的 t- PA活性治疗后均比治疗前明显升高 ,而 PAI- I活性明显降低 (均 P<0 .0 5及 <0 .0 1 ) ,组间比较苯那普利组升高及降低的幅度显著高于对照组 (P <0 .0 1 )。结论 :苯那普利对急性冠状动脉综合征患者的凝血系统无明显影响 ,但可使 t- PA活性增高而 PAI-
Objective:To investigate the effects of benazepril on coagulative and fibrinolytic system. Method:Forty eight patients with acute coronary syndrome were randomized into control group (n=16) and benazepril group (n=32). The control group received routine treatment, and the benazepril group were treated with routine therapy plus benazepril 10mg per day. Blood samples were drawn at the moment of admission and the 3 rd day after admission, respectively.Activated coagulative time (ACT), tissue type plasminogen activator (t PA) and plasminogen activator inhibitor 1 (PAI 1) were measured. Result:In PTCA group,the levels of serum CK MB at 5,30,120 min after PTCA were significantly higher than that before PTCA and those in two control groups at the same times (P< 0.01 ).In contrast,the levels of Mg 2+ at 5,30,120,360 min after PTCA were significantly lower than that before PTCA and those in the negative group at the same times (P< 0.05 ).In the positive group,the level of Mg 2+ at 5 min after operation was significantly lower than that before operation and those at the corresponding times in the negative group (P< 0.05 and P< 0.01 respectively).In addition,there was negative relationship between the level of CK MB and Mg 2+ at 30 min after PTCA (P< 0.001 ). Conclusion:Benazepril has no effect on the coagulation, but can increase the activity of t PA and decrease the activity of PAI Ⅰ.
出处
《临床心血管病杂志》
CAS
CSCD
北大核心
2001年第1期22-23,共2页
Journal of Clinical Cardiology
