摘要
低氧诱导因子1(hypoxia inducible factor 1,HIF-1)是细胞在低氧环境下调控的关键因子.当肝癌的失控生长导致细胞缺氧时,HIF-1的活性显著增强.为了使肝癌细胞适应低氧微环境,HIF-1通过激活多种与肿瘤生长相关的靶基因,参与调节了细胞增殖和凋亡、能量代谢、血管生成、侵袭转移以及耐受放疗和化疗等过程,最终促进了肝癌的发生和发展.由于HIF-1在肝癌细胞中的特异性表达以及介导肿瘤生长的特性,以HIF-1为新靶点的药物治疗和基因治疗已经成为目前的热门研究.这也为今后研发出肝癌的新辅助治疗技术提供了更广阔的思路.
Hypoxia inducible factor-1 （HIF-1） is a key regulator of the cellular response to hypoxia. Since cell growth is out of control in hepatocellular carcinoma （HCC）, HIF-1 activity is significantly enhanced in HCC to help cells adapt to the hypoxic microenvironment. HIF-1 plays a critical role in the occurrence and development of HCC through activating the target genes that participate in the regulation of cell proliferation and apoptosis, energy metabolism, angiogenesis, invasion and metastasis, resistance to chemotherapy and radiotherapy. Given the specific expression and regulation of HIF-1 in HCC growth, HIF-1 may become a new target for drug therapy and gene therapy, which provides a new avenue for neoadjuvant therapy of HCC in the future.
出处
《世界华人消化杂志》
CAS
北大核心
2014年第1期1-8,共8页
World Chinese Journal of Digestology
关键词
低氧诱导因子
肝癌
靶向治疗
Hypoxia inducible factor-1
Hepatocellular carcinoma
Targeted therapy
