摘要
背景:富血小板凝胶含有多种细胞生长因子,对于局部创伤及骨缺损的修复具有非常重要的作用。富血小板凝胶作为组织工程的支架的研究越来越多,但是对于其最优化的制备方法目前尚无统一标准。目的:简要综述近年来富血小板凝胶所含生长因子及制备方法的相关研究,总结多种富血小板凝胶的制备方法并进行比较,以此找出较为优化的制备方法。方法:以"富血小板血浆,富血小板凝胶,组织工程"为检索词检索中国期刊全文数据库(1980年1月至2013年1月),以"Platelet-rich plasma,Platelet-rich plasma gel,Tissue Engineering"为检索词检索PubMed数据库(1980年1月至2013年1月),纳入与富血小板凝胶检测及制备方法相关的研究,排除不相关学科及内容的研究,检索得到322篇相关文献,筛选后最终纳入67篇。结果与结论:目前富血小板凝胶的多种制备方法都存在各自的优势,不能单纯凭借某一项数据断定何种制备方法最好,需根据不同需要确定使用不同的方法。随着富血小板凝胶研究的不断深入,将会对创伤及骨缺损的临床修复以及组织工程研究起到至关重要的作用,也是未来组织工程支架研究的重要方向。
BACKGROUND： Platelet-rich plasma gel contains some kinds of growth factors, which play important roles in repair of local trauma and bone defects. Platelet-rich plasma gel is now more and more studied as tissue engineering scaffolds, but there are no unified preparation methods.
OBJECTIVE： To summarize the studies about the preparation methods of platelet-rich plasma gel and the growth factors in platelet-rich plasma gel in recent years, and to compare different methods in order to find which one is better.
METHODS： A online search of PubMed database from January 1980 to January 2013 and China National Knowledge Infrastructure from January 1980 to January 2013 was performed with the key words of ＂platelet-rich plasma, platelet-rich plasma gel, tissue engineering＂ in English and Chinese, respectively. The studies about detection and preparation methods of platelet-rich plasma were included and those unrelated to platelet-rich plasma were excluded. Finally, 322 articles were gained and 67 articles were included in result analysis.
RESULTS AND CONCLUSION： All preparation methods have their advantages. We should select the suitable method according to the goal of study. With the further study of platelet-rich plasma, it will become more and more important for bone defect repair and tissue engineering research.
出处
《中国组织工程研究》
CAS
CSCD
2014年第3期476-481,共6页
Chinese Journal of Tissue Engineering Research
基金
国家自然科学基金资助项目(81071509)~~
