摘要
目的:制备西罗莫司-羟丙基-β-环糊精(西罗莫司-HP-β-CD)分散片并考察体外溶出度。方法:以崩解时限为考察指标,采用星点设计方法对处方进行优选,比较西罗莫司-HP-β-CD分散片与普通片的溶出度。结果:分散片的性质符合规定,最佳工艺条件的崩解时限为134 s,分散片的溶出速度明显快于普通片。结论:西罗莫司-HP-β-CD分散片的处方组成合理,体外溶出度优于普通片。
OBJECTIVE To develop the formulation of sirolimus-hydroxypropyl β-cyclodextrin（Sirolimus- Hp-β-CD） dispersible tablets and study its dissolution in vitro. METHODS Formulation of the dispersible tablets was screened by central composite design using disintegration time as index. The dissolution of the dispersible tablets was compared with that of the con- ventional tablets. RESULTS The nature of the dispersible tablets accorded with regulation and the disintegration time of optimum technological conditions was 134 s. The dissolution of dispersible tablets was significantly faster than conventional tab- lets. CONCLUSION The formulation of sirolimus-HP-β-CD dispersible tablets was reasonable and the in vitro dissolution was better than conventional tablets.
出处
《中国医院药学杂志》
CAS
CSCD
北大核心
2014年第3期203-207,共5页
Chinese Journal of Hospital Pharmacy
关键词
西罗莫司
分散片
星点设计
溶出度
sirolimus
dispersible tablets β central composite design
dissolution
