摘要
目的:探讨丹红注射液对急诊经皮冠状动脉介入治疗(PCI)后急性心肌梗死(AMI)患者氧化应激和炎症反应的影响。方法:选取急诊PCI术后的AMI患者180例,随机分为丹红组(90例)和对照组(90例),两组均给予常规西医治疗;丹红组加用丹红注射液30 ml溶入0.9%氯化钠注射液250 ml,qd静脉滴注。两组均在治疗前及治疗后10 d分别测定血清中过氧化物歧化酶(SOD),高敏C-反应蛋白(hs-CRP)的含量。结果:(1)丹红组临床治疗效果显著优于对照组,两组比较差异有统计学意义(P<0.05)。(2)治疗10 d后两组血清SOD水平明显高于治疗前(P<0.05),而治疗组血清SOD水平又明显高于对照组(P<0.05)。两组治疗后血清hs-CRP水平均明显降低(P<0.05),且丹红组血清hs-CRP水平明显低于对照组(P<0.05)。结论:丹红注射液可以减少SOD的消耗量,有效清除自由基,抑制氧化应激,减轻炎症反应,从而稳定动脉粥样斑块,改善急诊PCI术后AMI患者预后。
OBJECTIVE To investigate the effects of Danhong injection on oxidative stress and inflammation reaction in patients with acute myocardial infarction undergoing pereutaneous coronary intervention（PCI）. METHODS 180 patients with acute myocardial infarction undergoing PCI were randomly divided into Danhong treatment group （n = 90） and control group（n = 90）. Conventional western medicines were given for patients in both groups except Danhong injection was given at the dose of 30 ml per day for patients in Danhong treatment group. The serum levels of SOD, hs-CRP were analyzed before and afterl0 days treatment. RESULTS （1） The clinical therapeutic efficacy was significantly different in patients with Danhong treatment compared to control group （P〈0. 05） ; （2） the serum level of SOD was significantly increased after 10days treatment in both Danhong and control groups though the increase was more obvious in Danhong treatment group. The serum level of hs-CRP in both groups was significantly decreased after 10 days treatment （P〈0.05）. And this decrease was more significant in Danhong treatment group compared to control group. CONCLUSION Danhong injection can reduce the consumption of SOD, effectively remove free oxygen radicals, suppress oxidative stress, and alleviate the inflammation reaction, so as to stabilize artery atheromatous plaque and improve prognosis in AMI patients undergoing PCI.
出处
《中国医院药学杂志》
CAS
CSCD
北大核心
2014年第3期215-218,共4页
Chinese Journal of Hospital Pharmacy
