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溃愈速联合明胶海绵对大鼠难愈性创面愈合的作用及机理研究 被引量:3

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摘要 目的探讨溃愈速与明胶海绵联合应用对大鼠难愈性创面修复的影响。方法将40只雄性SD大鼠制成全层皮肤缺损开放性创面,除正常创面对照组8只外,大鼠肌注氢化可的松琥珀酸钠制成难愈性创面模型后随机分成4组,医用凡士林对照组、溃愈速传统湿敷治疗组、溃愈速-明胶海绵治疗组、明胶海绵治疗组,每组8只。记录和观察创面色泽和渗液量,测定创面面积,病理切片组织学观察和成纤维细胞计数。结果医用凡士林对照组与正常创面对照组相比,创面愈合率低(P<0.05),愈合时间延长(P<0.05);溃愈速-明胶海绵治疗组与溃愈速传统湿敷治疗组和明胶海绵治疗组相比,创面渗液量较少,新生肉芽组织较多,成纤维细胞数量较多,愈合率高(P<0.05),愈合时间缩短(P<0.05),差异有统计学意义(P<0.05)。结论溃愈速与明胶海绵联合应用制成的溃愈速-明胶海绵创面敷料是一种优良的难愈性创面敷料。
出处 《时珍国医国药》 CAS CSCD 北大核心 2014年第1期63-65,共3页 Lishizhen Medicine and Materia Medica Research
基金 广东省中医药局基金资助项目(No.2010224)
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