摘要
目的 分析经鼻内镜下脑脊液鼻漏修补术后颅内感染的因素.方法 对173例经鼻内镜下脑脊液鼻漏修补术患者资料进行回顾性分析,采用SPSS 17.0软件对可能造成颅内感染的因素进行多因素Logistic逐步回归分析.结果 173例患者中,术后感染17例（9.83％）;脑脊液鼻漏修补失败（x2 =6.89,P=O.001）、颅底缺损直径＞1 cm（x2 =9.98,P =0.001）、既往有颅内感染病史（x2 =11.08,P=o.oo1）是经鼻内镜下脑脊液鼻漏修补术后颅内感染的影响因素（P值均＜0.05）,而性别、年龄、漏口位置、发病原因、术前是否应用抗菌药物和术后应用抗菌药物是否＞7d、手术是否使用人工材料对术后颅内并发感染影响不明显（P值均＞0.05）.结论 经鼻内镜下脑脊液鼻漏修补术后颅内感染受诸如脑脊液鼻漏修补失败、颅底缺损直径大小、既往颅内感染史等多种因素的影响.
Objective To analyze the factors of intracranial infection after transnasal endoscopic repair of cerebrospinal fluid rhinorrhea.Methods One hundred and seventy-three patients who accepted transnasal endoscopic repair of cerebrospinal fluid rhinorrhea were retrospectively analyzed.The intracranial infection factors was analyzed by Logistic regression analysis with SPSS 17.0 software.Results Postoperative infection was found in 17 cases among 173 patients,the infection rate was 9.83％.The unsuccessful transnasal endoscopic repair of cerebrospinal fluid rhinorrhea （x2 =6.89,P =0.001）,the defective diameter of skull base （x2 =9.98,P =0.001） and medical history of intracranial infection （x2 =11.08,P =0.001） were infection factors after transnasal endoscopic repair of cerebrospinal fluid rhinorrhea （all P ＜ 0.05）,while sex,age,the site of defection,the aetiological agent,longer application of antibiotics before or after operation and the use of artificial material had no obvious effect （all P ＞ 0.05）.Conclusion Intracranial infection after transnasal endoscopic repair of cerebrospinal fluid rhinorrhea is affected by many factors,such as the unsuccessful transnasal endoscopic repair of cerebrospinal fluid rhinorrhea,the defective diameter of skull base and medical history of intracranial infection.
出处
《中华耳鼻咽喉头颈外科杂志》
CAS
CSCD
北大核心
2014年第2期121-124,共4页
Chinese Journal of Otorhinolaryngology Head and Neck Surgery
关键词
内窥镜检查
耳鼻喉外科手术
脑脊液鼻漏
中枢神经系统感染
Endoscopy
Otorhinolaryngologic surgical procedures
Cerebrospinal fluid rhinorrhea
Central nervous system infections
