摘要
目的探讨氧化苦参碱(Oxymatrine,OM)保留灌肠对重症急性胰腺炎(Severe acute pancreatitis,SAP)的治疗作用及效果。方法选择SAP患者30例,随机分为对照组(15例)、OM灌肠组(15例)。对照组:确诊后每12 h应用温盐水500 mL灌肠清理肠道后,盐水100 mL保留灌肠;OM灌肠组:确诊后每12 h应用温盐水500 mL灌肠清理肠道后,OM溶液100 mL(OM 200 mg)保留灌肠。对照组和OM灌肠组确诊前1 d(D0)及确诊后第1、2、3天(D1、D2、D3)抽取静脉血,测定血浆D-乳酸、内毒素浓度。结果对照组与OM灌肠组D0及D1时,血浆D-乳酸浓度比较差异无统计学意义(P>0.05);D2、D3时,OM灌肠组与对照组比较,血浆D-乳酸浓度显著下降(P<0.01)。对照组与OM灌肠组D0及D1时,血浆内毒素浓度比较差异无统计学意义(P>0.05);D2、D3时,OM灌肠组与对照组比较,血浆内毒素浓度显著下降(P<0.05)。结论 OM保留灌肠治疗SAP,不但能减少肠内细菌含量,还能对肠黏膜屏障的损伤及细菌移位起到治疗作用。
Objective To evaluate the role of retention enema with oxymatrine （OM）in the treatment of severe acute pancreatitis（SAP）. Methods Thirty patients with SAP were randomly divided into OM drainage group （ n = 15 ） and control group（ n = 15 ）. After final diagnosis ,patients in the two groups were drainaged by 500 mL saline. After drainage ,patients in control group received 100 mL saline retention enema every 12 h, patients in OM drainage group received 100 mL OM solutions（ OM 200 mg）retention enema every 12 h. After treatment, the plasma endotoxin and D-lactic acid levels were determined before final diagnosis （DO）and on 1 st ,2nd, 3rd after diagnosis （D1, D2, D3 ）. Results There was no significant difference in plasma level of D-lactic acid between control group and OM drainage group at DO and D1 （ P 〉 0. 05 ） ; compared with control group, plasma D-lactic acid level of OM drainage group was significantly decreased at D2, D3 （ P 〈 0. 01 ）. There was no significant difference in plasma level of endotoxin between control group and OM drainage group at DO and D1 （P 〉 0.05 ） ; compared with control group, plasma endotoxin level of OM drainage group was significantly decreased at D2, D3 （ P 〈 0.05 ）. Conclusion Retention enema with OM in the treatment of SAP not only can reduce bacterial content in intestines but also improve mucosol barrier dysfunction to prevent bacterial translocation.
出处
《实用药物与临床》
CAS
2014年第2期131-134,共4页
Practical Pharmacy and Clinical Remedies
基金
国家自然科学基金资助项目(30840076)
辽宁省自然科学基金资助项目(20082058)
