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培美曲塞单药二线治疗晚期肺腺癌的疗效及其与血清胸苷酸合成酶的关系 被引量:2

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摘要 目的 探讨培美曲塞单药二线治疗晚期肺腺癌的疗效及其与血清胸苷酸合成酶(TS)的关系.方法 应用培美曲塞单药二线治疗48例(KPS≥60分)晚期肺腺癌患者,至少2个周期后进行疗效评价;治疗前1~2d取静脉血,ELISA法检测血清TS,分析其与培美曲塞单药二线治疗疗效的关系.结果 48例患者缓解率为10.4%,疾病控制率为56.2%;疾病控制患者血清TS为(57.27±38.05) pg/mL,进展患者为(99.38±59.07) pg/mL,P<0.05.结论 培美曲塞单药二线治疗晚期肺腺癌具有一定疗效,血清TS水平可作为判断其疗效的预测指标.
出处 《山东医药》 CAS 2014年第4期57-59,共3页 Shandong Medical Journal
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