摘要
目的 研究血清肿瘤标志物联合检测在结直肠癌患者诊断中的应用价值.方法 收集2010年1月至2012年9月河北医科大学第三医院肛肠科收治的120例结直肠癌患者作为观察组,80例结直肠良性疾病患者作为良性对照组,100例健康体检者作为健康对照组,采用全自动电化学发光仪检测各组患者外周血中癌胚抗原（CEA）、糖类抗原（CA）199和CA242的含量.对比观察组不同TNM分期患者之间外周血CEA、CA199和CA242水平;分析3项指标联合检测诊断结直肠癌的灵敏度和特异度.结果 观察组患者CEA、CA199和CA242水平明显高于良性对照组和健康对照组,并且在观察组患者3项指标水平均为TNM Ⅰ期＞Ⅱ期＞Ⅲ期＞Ⅳ期.3项指标联合检查灵敏度为80.00％,特异度为97.78％,均高于3项指标单独检测（灵敏度和特异度分别为CEA：17.50％、73.89％,CA199：29.17％、67.22％,CA242：71.67％、68.89％,均P＜0.05）.结论 CEA、CA199和CA242联合检查能提高结直肠癌诊断的灵敏度和特异度,具有积极的临床价值.
Objective To study the diagnostic value of combined detection of three serum tumor markers in patients with colorectal cancer.Methods Between January 2010 and September 2012,120 patients with colorectal cancer in the Third Hospital,Hebei Medical University （observation group）,80 patients with benign colorectal diseases （benign control group） and 100 individuals who underwent health check-up （healthy control group） were recruited.The Roche Elecsys 2010 automatic electrochemical luminescence instrument was employed to detect the levels of carcinoembryonic antigen （CEA）,carbohydrate antigen（CA） 199 and CA242 in peripheral blood,which entailed comparison on the difference among various TNM stages and analysis of the assay sensitivity and specificity of their combination.Results The observation group yielded significantly higher levels of CEA,CA199 and CA242 compared with benign and healthy control group.The levels of these indices followed the order of TNM Ⅰ,Ⅱ,Ⅲ and Ⅳ respectively,based on the staging.The combination of three indices yielded the assay sensitivity and specificity of 80.00％ and 97.78％,which were higher than those of either parameter alone （CEA：17.50％ and 73.89％,CA199：29.17％ and 67.22％,CA242：71.67％ and 68.89％,all P＜0.05）.Conclusion The combined detection of CEA,CA199 and CA242 improves the assay sensitivity and specificity of colorectal cancer and is worthwhile for clinical practice.
出处
《中华生物医学工程杂志》
CAS
2013年第5期394-396,共3页
Chinese Journal of Biomedical Engineering
