5De Angioletti M, Rovira A, Sadelain M, et al . Frequency of missense mutations in the coding region of a eukaryotic gene transferred by retroviral vectors[J]. J Virol. 2002,76(4):1991 - 1994.
6Bestor TH. Gene silencing as a threat to the success of gene therapy[J]. J Clin Invest. 2000,105(4) :409 - 411.
7Rainov NG, Kramm CM, Banning U, et al. Immune response induced by retrovirus - mediated HSV - tk/GCV pharmacogene therapy in patients with glioblastoma muhiforme[J]. Gene Ther. 2000,7(21) :1853 - 1858.
8Meyer F, Finer M. Gene therapy : progress and challenges. Cell Mol Biol, 2001,47(8) : 1277 - 1294.