摘要
目的 探讨肺癌组织中高迁移率族蛋白-1（HMGB-1）、VEGF和MMP-9与微血管生成的相关性.方法 选择肺癌患者标本80例为研究对象,癌组织作为观察组,癌旁正常肺组织作为对照组,采用免疫组化染色测定组织中HMGB-1、VEGF、MMP-9和MVD的表达情况.结果 观察组肺组织HMGB-1、VEGF和MMP-9的表达均明显高于对照组（χ^2=6.27、5.93、5.16,均P＜0.05）.观察组MVD值为（76.27±19.24）个,对照组为（24.67±6.14）个,两组差异有统计学意义（t=6.764,P＜0.01）.HMGB-1、VEGF和MMP-9均与MVD呈正相关关系（r=0.430、0.506、0.597,均P＜0.05）.结论 肺癌组织中HMGB-1、VEGF和MMP-9与微血管生成有密切关系.
Objective To study the correlation of high mobility group box-1 （ HMGB-1 ）, vascular endothelial growth factor （ VEGF ） and matrix metalloproteinase-9 （ MMP-9 ） with angiogenesis in lung cancer tissue. Methods The lung tissues of 80 cases with non-small cell lung cancer were selected. The cancerous tissues were enrolled into the observation group, and adjacent tissues were selected as the control group. HMGB-1, VEGF, MMP-9 and MVD expression were determined by immunohistochemical staining. Results The expressions of HMGB-1, VEGF and MMP-9 in the observation group were significantly higher than those in the control group（ ~2 = 6.27,5.93,5.16, all P 〈 0.05 ）. MVD value of the observation group was （76.27 ＋ 19.24 ）, that of the control group was （24.67 ＋ 6. 14） ,there was significant difference between the two groups （t = 6. 764, P 〈 0.01 ）. HMGB-1, VEGF and MMP-9 were positively correlated with MVD （ r = 0. 430,0. 506,0. 597, all P 〈 0.05 ）. Conclusion In lung cancer tissue, HMGB-1, VEGF and MMP-9 were closely related with angiogenesis.
出处
《中国基层医药》
CAS
2014年第3期346-348,共3页
Chinese Journal of Primary Medicine and Pharmacy
