摘要
抗血小板药物的临床应用是心脑血管疾病治疗领域的里程碑,但是随着应用时间的延长及"双重"甚至"三重"抗血小板药物的联用,其不良反应如抗血小板药物抵抗或出血风险的发生率大增,因此寻找新的安全有效的抗血小板药物或改善抗血小板药物抵抗的方法,成为目前心脑血管疾病防治领域的国际性关注点.活血化瘀中药具有明确的抗血小板及抗动脉粥样硬化的临床疗效,从传统活血化瘀中药中筛选出高效、低副作用的抗血小板药物近年来引起国内外学者的极大关注.本文对近年来国内外活血化瘀中药抗血小板治疗作用的研究进展作一评述.
The development of oral antiplatelet drugs represents a milestone in the treatment of atherothrombotic cardiovascular diseases. However, the efficacy and safety of prolonged treatment with double or triple anti-platelet drugs, has garnered particular attention in clinical practice. The development of novel classes of antiplatelet agents, with improved efficacy and fewer adverse effects, for the prevention of cardiovascular disease is therefore intensely researched worldwide. Chinese herbs and formulas that activate blood circulation also possess antiplatelet and antiatherosclerotic activities. These Chinese medicinal herbs and formulas have therefore drawn attention among scientists, because they may be more effective and safer compared with currently used therapies. However, the mechanistic basis for this antiplatelet activity remains unclear. This article will review progress made in uncovering the mechanism underlvinu the antiolatelet activitv of Chlne^e herh~ ~nd fnrmllln~ thnt ~pt^v~t~ hlc~,-I o~ 1~
出处
《科学通报》
EI
CAS
CSCD
北大核心
2014年第8期647-655,共9页
Chinese Science Bulletin
基金
国家自然科学基金(30901949
81073086
81030063
81102845)资助
关键词
活血化瘀
中药
抗血小板
作用机制
心血管疾病
activate blood circulation, Chinese medicine, antiplatelet, mechanism, cardiovascular disease
