摘要
目的探讨血清CA72-4、CEA和CA19-9对胃癌的诊断价值及其与病理特征的相关性。方法采用电化学发光方法测定112例胃癌患者、52例胃良性疾病患者和35例健康对照者血清中CA15-3、CA125、CA72-4、CEA和CA19-9水平,应用SPSS18.0统计软件包进行统计学分析。结果胃癌患者CA72-4水平与胃良性疾病组、对照组间有显著差异,胃良性疾病组与健康对照组之间无显著差异;胃癌组CEA、CA19-9水平与胃良性疾病组、对照组之间无显著差异。CA15-3、CA125、CEA、CA19-9和CA72-4对胃癌诊断价值的ROC曲线下面积分别为0.410、0.624、0.650、0.655和0.754。提示CA15-3没有诊断价值,CA125、CEA、CA19-9诊断价值较低,CA72-4诊断价值中等。在胃癌诊断中CA19-9、CEA、CA72-4组合与CA72-4单项检测没有差异。CA72-4、CEA、CA19-9水平与病理特征的关系:CEA在患者性别、组织分型上,CA72-4在主癌大小、大体分型、肿瘤浸润深度、淋巴结转移和临床TNM分期上的差异有统计学意义(P<0.05)。结论 CA72-4对胃癌诊断有一定价值,且其水平变化与胃癌进程相关。
Objective To investigate the correlation between the diagnostic value of serum CA72-4, CEA and CA19-9 for gastric cancer and patho- logical features. Methods The levels of serum CA72-4, CEA and CA19-9 were detected by eleetrochemolumineseenee immunoassay in 112 gas- tric cancer patients, 52 patients with benign gastric diseases and 35 control groups, SPSS18.0 software package was used for statistical analysis. Re- sults The level of serum CA72-4 in patients with gastric carcinoma was obviously higher than those in patients with benign gastric diseases and in normal controls, no difference between benign gastric diseases and control groups, while the levels of serum CEA and CA19-9 in patients with gastric cancer showed no significant difference with the other two groups. ROC curves showed that the under-curve area of CA15-3, CA125, CEA, CA19-9 and CA72-4 were 0.410,0.624,0.650,0.655 and 0.754 respectively. CA15-3 presented no diagnostic value. CA125, CEA, CA19-9 have low diag- nostic value while CA72-4 medium. The combination detection of CA19-9, CEA, CA72-4 showed no difference with CA72-4 in the diagnosis of gas- tric caner. Comparison among CA72-4, CEA, CA19-9 levels and pathological features ： it has statistical significance （P 〈 0.05 ） with CEA on patient sex, histologic classification, and CA72-4 in primary carcinoma size, arbitary classification, tumor infiltration depth, lymph node metastasis and the difference in clinical TNM staging. Conclusion CA72- 4 has a certain value for early diagnosis of gastric cancer, the statistical difference of CA72- 4 between gastric cancer pathologies groups, account for the relation of CA72-4 levels with gastric cancer process.
出处
《中国医科大学学报》
CAS
CSCD
北大核心
2014年第3期259-262,274,共5页
Journal of China Medical University
基金
辽宁省社会发展基金(2011225019)
