摘要
迄今,寄生虫病仍是全球范围内,特别是发展中国家的重要公共卫生问题之一.随着免疫学和分子生物学技术的发展,寄生虫疫苗已成为防治寄生虫病的重要手段之一.其中疫苗免疫剂量是影响其免疫效果的重要因素之一.疫苗的剂量过低,不能刺激机体产生足够强的免疫反应;剂量过高,则可能引起免疫耐受或毒性反应,因此,确定合适的免疫剂量是疫苗研究的关键.该文就血吸虫、弓形虫和旋毛虫等寄生虫疫苗免疫剂量的研究现状作一综述.
So far parasitic disease is still the one of the most important public health problems world- wide, especially in the developing countries. With the development of immunology and molecular biology technology, the parasite vaccine has become one of the important means of controlling parasitic diseases. Im- mune dose of the parasitic vaccine is one of the important factors for the immune effects. If the dose of vac- cine is too low, the body can＇t be stimulated to produce enough immune response; if the dose of vaccine is too high, it may cause immune tolerance or toxic reactions. Therefore, to determine the appropriate immunization dose is the key of vaccine research. This article reviewed the researeh status of immune dose of several para- site vaccines, such as Schistosoma, Toxoplasma gondi and Trichinella spirolis.
出处
《国际医学寄生虫病杂志》
CAS
2014年第2期90-93,共4页
International JOurnal of Medical Parasitic Diseases
基金
国家自然科学基金（81160206）
贵州省教育厅资助项目（2010040）
贵州省科技厅社会攻关项目（黔科合SY字[2011]3038号）
