摘要
目的探讨幽门螺旋杆菌(HP)感染对反流性食管炎(RE)发病和治疗的影响。方法收集西安市中心医院2011年6月至2013年6月的门诊病人642例,记录其性别、年龄、体重、反流性食管炎分级及HP感染严重程度。结果 RE组HP(+)感染率明显高于HP(-),差异有统计学意义(P<0.05),而非RE组HP(+)感染率与HP(-)间无明显差异(P>0.05)。b组(C-D级)患者HP感染(++/+++)明显高于a组(A-B级),差异有统计学意义(P<0.05)。A组(HP根除+PPI)与B组(PPI)GERD-Q评分、心理SF-36评分和生理SF-36评分相比无明显差异(P>0.05)。结论HP感染与反流性食管炎的发病可能存在一定的关联,根除HP未能明显改善反流性食管炎的预后。
Objective This study is designed to find out the influence ofHelicobacterpylori （HP） on gastro esophageal reflux disease （GERD）. Methods The study was conducted retrospectively at our Hospital between June 2011 and June 2013. Age, sex, weight, the grade of reflux esophagitis（RE） and the severity of HP of the patients were collected. Results HP （＋） infection rate of RE group was significantly higher than that of HP （-） （P〈0.05）, and there is no significant difference between HP （＋） infection rate and HP （-） in non RE group（P〉0.05）. HP infection （＋＋/＋＋＋） in group b（grade C-D） was higher than that in group a （grade A-B）（P〈0.05）. There were no significant difference of GERD-Q score, physical SF-36 score and psychological SF-36 scores between group A （HP＋PPI eradication） and group B （PPI） （P〉0.05）. Conclusion HP infection is correlated with the pathogenesis of reflux esophagitis, eradication of HP could not obviously improve prognosis of reflux esophagitis.
出处
《热带医学杂志》
CAS
2014年第2期181-183,共3页
Journal of Tropical Medicine
