摘要
在不添加催化剂的情况下,通过聚乙二醇单甲醚(mPEG)引发5,5-二甲基-1,3-二噁烷-2-酮(DTC)本体开环聚合,得到了生物可降解脂肪族聚(碳酸酯-co-乙二醇)(DMP)两亲性嵌段共聚物。将其与叶酸(FA)反应,合成了末端含有叶酸的生物可降解两亲性嵌段共聚物(FA-DMP)。所得聚合物结构经傅里叶变换红外光谱(FT-IR)、核磁共振谱(1 H-NMR)、紫外光谱(UV-Vis)、凝胶渗透色谱(GPC)表征。利用聚合物FA-DMP的两亲性结构特点,采用透析法制备了其聚合物胶束。结果表明,在不添加任何催化剂的情况下,利用mPEG的端羟基可成功引发DTC开环聚合,且通过改变投料比可调控DMP嵌段共聚物的分子量;FA-DMP聚合物可形成具有一定纳米尺寸的胶束,且其粒径与聚合物的亲水-疏水链链长有关。
Biodegradable copolymers of poly（5,5-dimethyl-1,3-dioxan-2-one）-b-methoxy poly（ethylene glycol） （DMP） were synthesized by the ring-opening polymerization of 5,5-dimethyl-1,3-dioxan-2-one （DTC） in bulk with methoxy poly（ethylene glycol） （mPEG） as initiator in the absence of catalyst. Then biodegradable amphiphilic copolymers with end group folate （FA-DMP） were obtained by reaction of DMP with folate（FA）. The resulting copolymers were characterized by Fourier Transform Infrared Spectra （FT-IR）, 1H-Nuclear Magnetic Resonance （1H-NMR）, Ultraviolet Spectra （UV）, and Gel Permeation Chromatography （GPC）. Micelles self assembled from FA-DMP copolymers were prepared through dialysis method. Results showed that mPEG could effectively initiate the ring opening polymerization of DTC without catalyst, and that the molecular weight of DMP copolymers could be adjusted by changing the molar feed ratio of DTC to mPEG. The folate-conjugated DMP copolymers could form nano-micelles, and the size was related to the hydrophilic-hydrophobic chain length of copolymer.
出处
《功能高分子学报》
CAS
CSCD
北大核心
2014年第1期29-33,66,共6页
Journal of Functional Polymers
基金
湖北省自然科学基金项目(2010CDB03501)
煤转化与新型炭材料湖北省重点实验室开放基金项目(WKDM201105)
关键词
脂肪族聚碳酸酯
聚乙二醇
叶酸
胶束
aliphatic polycarbonate
polyethylene glycol
folate
micelle
