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新生儿重度高胆红素血症病因及预后分析 被引量:13

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摘要 目的:探讨新生儿重度高胆红素血症的病因及近远期预后。方法对2008年6月至2012年6月在本院治疗的132例重度高胆红素血症患儿(总胆红素>342μmol/L)进行临床资料回顾性分析,通过随访1~5年后患儿听力、智力、神经系统发育情况,了解重度高胆红素血症的病因及近远期预后。结果感染占新生儿重度高胆红素血症病因的第一位(38.64%),其次是不明原因黄疸(31.06%)和新生儿溶血病(21.21%);132例患儿出院时,127例治愈,3例好转,2例死亡。经1~5年后随访96例患儿,8例有听力损害,2例有神经系统改变,4例有不同程度智力损害,其他患儿预后良好。且其预后与血清胆红素峰值无显著相关性。结论感染为该地区新生儿重度高胆红素血症病因的第一位;胆红素对脑干听觉通路的毒性作用可能是暂时的,若治疗及时,后期可恢复;对新生儿重度高胆红素血症,单凭血清胆红素峰值并不能确切预测远期预后,及早发现和治疗,其近远期预后良好。
出处 《中华临床医师杂志(电子版)》 CAS 2014年第2期150-153,共4页 Chinese Journal of Clinicians(Electronic Edition)
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参考文献15

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