摘要
目的 探讨酒依赖患者酒精戒断初期睡眠障碍的特点,及其与饮酒渴求程度的关系,为临床诊治和防止复饮提供帮助.方法 以32例住院治疗的酒依赖患者为酒依赖组,20例男性健康志愿者为对照组,在酒精戒断后第2周内,酒依赖组采用宾夕法尼亚酒精渴求量表（Pennsylvania Alcohoi Craving Scale,PACS）进行饮酒渴求评定；两组均进行整夜多导睡眠图（Polysomnogram,PSG）描记.结果 酒依赖组PACS量表5条目评分分别在3.48～4.26分之间,PSG检测该组睡眠潜伏期（42.48±22.42） min、总睡眠时间（289.61±103.22） min、睡眠效率（71.45±19.86）％、S1睡眠（23.47±11.07）％、觉醒次数（8.01±2.77）次、S3＋4睡眠（6.26±5.35）％,与对照组比较[分别为（19.65-±8.57） min,（407.33±21.29） min,（81.52±6.46）％,（8.79±1.83）％,（2.17±1.04）次,（15.87±5.24）％]差异有统计学意义（t=2.206～ 9.082,P＜0.05～0.001）；酒精渴求程度与睡眠潜伏期、觉醒次数、S1呈正相关（r=0.424 ～ 0.898,P＜0.05～ 0.01）,与总睡眠时间、睡眠效率、S3＋4呈负相关（r=-0.416～-0.662,P＜0.05～0.01）.结论 酒依赖戒断初期存在有睡眠连续性和睡眠结构障碍,且与饮酒的渴求程度有关,临床酒依赖治疗中应注意改善其睡眠障碍症状.
Objective To explore the characteristic of sleep disorders in the initial stage of withdrawal and their relationships with alcohol craving levels in alcohol dependence （AD） patients, and provide support for di- agnosis and prevention of re-drinking. Methods Thirty-two AD inpatients were assigned to AD group and 20 male healthy volunteers to control group. Alcohol craving was assessed with the Pennsylvania Alcohol Craving Scale （PACS） within the 2nd week after alcohol withdrawal for AD patients, and then the whole-night polysomnogram （PSG） tracings were conducted on the day of the night. Results The five item scores of the PACS were from 3.48 to g. 26 in AD patients. The sleep latency was （ 42.48 ± 22.42 ） rain, total sleep time was （ 289.61 ± 103.22 ） min, sleep efficiency was （ 71.45± 19.86） %, S1 sleep was （ 23.47± 11.07 ） % , arousal frequencies was （ 8.01 ± 2.77 ） , S3±4 sleep was（6.26±5.35） % in AD group.Compared with control group（（19.65±8.57） min, （407.33±21.29） min, （81.52 ~：6.46 ） %, （ 8.79± 1.83 ） %, （ 2.17± 1.04）, （15.87±5.24） % respectively）, the differences had statistical signifi- cances（ t=2.206-9.082, P〈0.05-0.001）. Alcohol craving levels were positively related to sleep latency, arousal frequencies and S1 sleep （ r=0.424-0.898, P〈0.05-0.01 ） and negatively to total sleep time, sleep efficiency and $3~4 sleep （ r=-0.d16-0.662, P〈0.05-0.01） in AD group. Conclusion AD patients have sleep continuity and structure disturbances in the initial stage of alcohol withdrawal, sleep continuity and structure disturbances are re- lated to alcohol craving. Improvements of sleep disorders should be paid during clinical alcohol dependence treat- ment.
出处
《中华行为医学与脑科学杂志》
CAS
CSCD
北大核心
2014年第3期222-224,共3页
Chinese Journal of Behavioral Medicine and Brain Science
基金
河南省医学科技攻关计划项目（201303109）
关键词
酒依赖
渴求
睡眠障碍
Alcohol dependence
Craving
Sleep disorders
