摘要
目的探讨颈动脉斑块积分对糖尿病视网膜病变(DR)的诊断价值。方法选择2010年6月—2012年12月在北京大学人民医院眼科和内分泌科确诊的DR患者120例(200只眼)为观察组,2型糖尿病无眼底病变患者50例(100只眼)为对照组;再将观察组患者分为非增殖期糖尿病视网膜病变组(NPDR组,60例)和增殖期糖尿病视网膜病变组(PDR组,60例)。采用彩色多普勒超声诊断仪检查所有患者双侧颈动脉并计算颈动脉斑块积分。绘制ROC曲线以评价颈动脉斑块积分对DR的诊断价值。结果对照组颈动脉斑块积分为(1.14±1.26)分,PDR组为(2.64±1.38)分,NPDR组为(1.80±1.64)分,PDR组颈动脉斑块积分大于NPDR组和对照组(q值分别为4.502和7.665,P<0.01),NPDR组大于对照组(q=3.373,P<0.05)。颈动脉斑块积分诊断DR的曲线下面积为0.720,颈动脉斑块积分为2.5分时诊断DR的敏感度为52%,特异度为86%,约登指数最大,为0.38。结论随着颈动脉斑块积分的增加,DR严重程度也随之增加;颈动脉斑块积分对DR具有较高的诊断价值,颈动脉斑块积分≥2.5分可作为预测DR较好的指标。
Objective To investigate the value of carotid artery plaque score in diagnosis of diabetic retinopathy （DR）. Methods A total of 120 DR patients （200 eyes） admitted to People＇s Hospital of Peking University from June 2010 to December 2012 were enrolled as study group, 50 T2DM patients without fundus lesions （100 eyes） as control group. The study group were subdivided into groups proliferating DR （ PDR group, n = 60） , non - PDR （ NPDR group, n = 60）. Color Doppler ultrasound was used to check patients＇bilateral carotid arteries and calculate carotid plaque scores. ROC curve was drawn to eval- uate the value of carotid plaque scores in diagnosis of DR. Results The carotid plaque scores were （ 1.14 ＋ 1.26 ） in control group, （2. 64 ＋ 1.38） in PDR group, （1.80 ＋ 1.64） in NPDR group, higher in PDR group than in groups NPDR, control, respectively （q = 4. 502, 7. 665, P 〈 0.01 ）, higher in NPDR group than in control group （ q = 3. 373, P 〈 0. 05 ）. The area under curve of carotid plaque scores diagnosing DR was 0. 720. When carotid plaque score was 2. 5, the sensitivity was 52% , specificity was 86%, the Youden index was the biggest （0. 38 ）. Conclusion Carotid plaque score is of high value in DR diag- nosis. Carotid plaque score〉2. 5 can be used as a good indicator predicting DR.
出处
《中国全科医学》
CAS
CSCD
北大核心
2014年第5期513-515,共3页
Chinese General Practice
关键词
糖尿病
2型
糖尿病视网膜病变
颈动脉斑块
诊断
Diabetes mellitus, type 2
Diabetic retinopathy
Carotid artery plaque
Diagnosis
