摘要
目的探讨和观察中空羟基磷灰石复合rhBMP-2在骨缺损修复过程的再血管化。方法将48只成年的新西兰雄性大白兔制作成桡骨骨缺损模型,随机分3组,各组分别植入以下材料:中空HA/rhBMP-2复合人工骨、单纯中空HA人工骨、单纯rhBMP-2。植入后于4、8、12、16周分别注射99mTc-MDP进行放射性核素骨显像并监测骨缺损修复过程中再血管化情况,同时进行大体、X线、组织学观察。结果术后各时间段,中空HA/rhBMP-2复合人工骨组在X线及放射性核素聚集强度明显高于单纯中空HA人工骨组(P<0.05),表现为成骨代谢活跃及早期的再血管化能力。结论中空HA/rhBMP-2复合人工骨具有良好的骨缺损修复能力,成骨活性持久,再血管化能力强,有望成为一种理想的骨缺损修复材料。
Objective To study and observe the revascularization process of the hollow hydroxyapatite composite rhBMP-2 in repairing the bone defect. Methods 48 adult male New Zealand rabbits with artificially-established radius defect were randomly divided into 3 groups, each group were implanted with the following materials： hollow HA/rhBMP-2 composite artificial bone（A groups）, hollow HA （B groups）,rhBMP-2（C groups）. After implantation in 4, 8, 12, 16 weeks, the process was observed using radionuclide bone imaging, X ray, histological observation. Results Different time after the operation, X- ray and histological score, bone radionuclide-gathering strength of the rabbits in the hollow HA/rhBMP-2 composite artificial bone group in the were higher than that of hollow HA artificial bone （P 〈 0.05）. In the control group, synostosis and bone sclerosis were observed in bone defect area bone defect failed to heal. Conclusion Hollow HA/ rhBMP-2 composite artificial bone has good ability in revascularization and repairing segmental bone defect and is expected to be an ideal material for bone defect repair.
出处
《中国临床解剖学杂志》
CSCD
北大核心
2014年第2期196-200,共5页
Chinese Journal of Clinical Anatomy
关键词
重组人骨诱导蛋白-2
中空羟基磷灰石
骨缺损
再血管化
Recombinat human bone inducing protein- 2
Hollow hydroxyapatite
Bone defect
Revascularization
