摘要
目的评价微量泵泵入阿托品和间断静脉推注阿托品治疗有机磷中毒的临床疗效和安全性。方法计算机检索Cochrane图书馆、Cochrane临床对照试验资料库、Medline、EMBase、OVID、SD、中国生物医学文献数据库、万方数据库、中国知网全文数据库2004年1月—2012年10月有关微量泵泵入和间断静脉推注阿托品治疗有机磷中毒的随机对照试验,并进行Meta分析。结果共纳入14篇关于两种不同的阿托品给药方式治疗有机磷中毒的随机对照试验。Meta分析结果显示:微量泵泵入和间断静脉推注阿托品达到阿托品化时间比较,差异无统计学意义(P=0.92);两种方法治疗有机磷中毒的病死率及阿托品中毒、有机磷中间综合征、反跳现象发生率比较,差异均有统计学意义(P<0.05)。结论微量泵泵入与间断静脉推注阿托品治疗有机磷中毒达到阿托品化时间无差异,微量泵泵入阿托品可降低病死率,减少阿托品中毒、有机磷中间综合征及反跳现象的发生率,具有较好的安全性。
Objective To evaluate the clinical efficacy and safety of atropine using two different kinds of drug - deliv- ery way （microinfusion pump and intermittent intravenous injection ） in treatment of patients with organophosphorus poisoning （OP） . Methods We searched in the Coehrane library, Coehrane controlled trials register, Medline, EMBase, OVID, SD, CBM, WanFang database and CNKI to identify studies on randomized controlled trials （RCTs） about two different kinds of drug - delivery way in treatment of patients with 019 by atropine from January 2004 to October 2012, then a Meta - analysis was per- formed. Results 14 RCTs about two different kinds of drug - delivery way in treatment of patients with OP by atropine were in- cluded. All the results of Meta analysis were listed as the following： There was no significant difference in the time of atropiniza- tion between microinfusion pump group and intermittent intravenous injection group （P = 0. 92）; There were significant differ- ences in the mortality of OP, incidence rate of atropine poisoning, intermediate syndrome and rebound phenomenon between two groups （ P 〈 0.05 ） . Conclusion There is no difference in the time of atropinization between microinfusion pump method and intermittent intravenous injection method, atropine treatment by microinfusion primp can reduce mortality and incidence rate of at- ropine poisoning, the intermediate syndrome and rebound phenomenon, and has relative good security.
出处
《中国全科医学》
CAS
CSCD
北大核心
2014年第6期671-674,682,共5页
Chinese General Practice
关键词
阿托品
有机磷中毒
输注泵
META分析
Atropine
Organo phosphorus poisoning
Infusion pumps
Meta - analysis
