摘要
目的通过对如皋市耐多药肺结核(MDR-TB)患者的来源及转归进行分析,探索适合该地区MDR-TB的发现策略。方法 2010-2013年收集该市所有涂阳结核病患者的痰标本,开展药敏检查,分析不同来源患者中的MDR-TB发现及转归情况。结果 4年间确诊MDR-TB患者36例,结核病患者中MDR-TB检出率为9.3%,其中86.1%的MDR-TB患者来源于MDR-TB高危人群。初治凃阳者MDR-TB检出率为1.7%,MDR-TB高危人群为34.8%,差异有统计学意义(P<0.001)。MDR-TB高危人群中,慢性排菌患者MDR-TB检出率为57.1%,复发患者为34.7%,其他复治患者为22.2%,2月或3月末未发现涂片仍阳性者。纳入治疗的MDR-TB患者治疗成功率为67.7%。不同来源的MDR-TB高危人群MDR-TB检出率及治疗成功率差异均无统计学意义(P>0.05)。结论该市MDR-TB疫情低于全国水平,MDR-TB高危人群是该市发现耐多药肺结核最主要人群。
Objective To analyze sources and outcomes of multi-drug resistant tuberculosis （MDR-TB） patients in Rugao to search for proper detection strategy for MDR-TB patients. Methods From 2010 to 2013, sputum specimens of sputum smear positive patients were collected and subjected to susceptibility test. The detection and treatment outcomes of MDR-TB patients were analyzed. Results Totally 36 MDR-TB patients were confirmed from 2010 to 2013,accounted for 9.3% of of TB patients. 86.1% of MDR-TB patients were identified from high-risk MDR-TB populations. MDR-TB patients accounted for 1.7% and 34.8% of patients in initial sputum smear positive group and MDR-TB high risk populations, respectively, with sig- nificant difference （P〈0. 001）. Among MDR-TB high risk populations, MDR-TB patients accounted for 57. 1M, 34. 7%, 22.2 % of long positive sputum bacillus patients and relapse patients, other patients for retreatment and patients, respectively. No MTR-TB patients were identifien from patients whose sputum smear was still positive at the end of Feb or Mar. Treatment for MDR-TB patients was 67.7% successful for involved cases. No significant difference was observed on detection rate or treatment success rate among high risk MDR-TB populations from different sources（P〉0.05）. Conclusion MDR-TB epidem- ic in Rugao is below national level, high-risk MDR-TB population is major source of multidrug-resistant TB patients.
出处
《江苏预防医学》
CAS
2014年第2期31-33,共3页
Jiangsu Journal of Preventive Medicine
