摘要
以5-氯-1-茚酮为起始原料,经羰基化、不对称氧化、腙化和缩合反应合成了高效杀虫剂茚虫威的关键中间体2-(苯甲基)-7-氯茚并[1,2-e][1,3,4]噁二嗪-2,4a(3H,5H)-二羧酸4a甲酯。以5-氯-1-茚酮计,产品总收率达61.1%,产品结构经核磁共振分析验证。探讨了原料配比、溶剂的选择、氧化剂等因素对反应收率的影响。
Using 5-chloro-l-indone as starting material, 4a-methy-2-phenyhnethy-7-chrinden[2-e][34]xadiazine-24a（3H5H）dicarbxyate was synthesized by carbonylation, asymmetric oxidation, hydrazone and condensation, in a total yield of 61.1%, which is a key intermediate of indoxacarb. The structure of product was confirmed by NMR analysis. The influence of the ratio of reactants, solvent selection and oxygenant on the yield was investigated.
出处
《广东化工》
CAS
2014年第7期6-7,共2页
Guangdong Chemical Industry
