摘要
目的：探讨血管生成抑制蛋白1（VASH1）在食管鳞状细胞癌（ESCC）组织中的表达及意义。方法：用免疫组化SP法检测112例ESCC和36例正常食管组织中VASH1的表达，对随访资料进行Kaplan-Meier生存分析和Cox回归分析。结果：VASH1蛋白在ESCC组织中的阳性表达率为76．8％（86/112），在正常组织中的阳性表达率为11．1％（4/36），差异有统计学意义（χ2＝49．307，P＜0．001）；VASH1蛋白在ESCC组织中的表达与肿瘤浸润深度、淋巴结转移、TNM分期有关（P＜0．05）；Log-rank检验显示VASH1蛋白阳性表达ESCC患者的生存时间明显低于阴性表达者（χ2＝9．547，P＝0．002）；Cox回归分析显示淋巴结转移、TNM分期及VASH1蛋白的表达可作为ES-CC预后的独立危险因素[RR（95％CI）＝2．334（1．472～3．699）、2．109（1．428～3．326）、2．212（1．299～3．766）]。结论：VASH1可能在ESCC的发展、浸润、转移中起抑制作用。
Aim： To explore the expression of vasohibin 1（VASH1） in esophageal squamous cell carcinoma（ESCC）. Methods：Immunohistochemistry was used to detect the expression of VASH1 in 112 cases of ESCC and 36 cases of normal e-sophageal tissue.Follow-up data were analyzed by Kaplan-Meier survival analysis and Cox regression analysis .Results：The positive rate of VASH1 protein in ESCC tissue was 76.8%（86/112）, which was 11.1%（4/36）, and the difference was statisti-cally significant （χ^2=49.307,P〈00.01 ）;the expression of VASH1 in ESCC tissue was significantly correlated with tumor depth of invasion, lymph node metastasis, and TNM stage（ P〈0.05）, log-rank test results showed that survival time of VASH1 posi-tive expression group was significantly lower than the negative expression group（χ^2=9.547,P=0.002）;Cox regression analysis showed that lymph node metastasis, TNM stage and VASH1 expression can be used as an independent risk factor for prognosis of ESCC[RR（95% CI）=2.334（1.472-3.699）,2.109（1.428-3.326）,2.212（1.299-3.766）].Conclusion：VASH1 possibly plays a role in inhibiting development, invasion and metastasis of ESCC.
出处
《郑州大学学报（医学版）》
CAS
北大核心
2014年第2期150-152,共3页
Journal of Zhengzhou University(Medical Sciences)
