摘要
子宫内膜异位症(EMS)是临床上最常见的妇科疾病之一,术后的复发问题一直困扰着临床医师。促性腺激素释放激素激动剂(GnRH-a)的使用对于降低EMS术后的复发具有十分重要的作用,目前已成为临床上最为常用的预防EMS复发的方法。但是,GnRH-a使用后引发的围绝经期症状严重影响患者的生活质量,部分患者因此而终止治疗。激素反向添加治疗虽然很好的解决了围绝经期症状,但是激素的长期使用可能导致激素依赖性疾病的风险。作为一种植物提取物,黑升麻制剂能否较好的拮抗GnRH-a所致类围绝经期症状,而且又能避免激素反向添加治疗的风险,目前尚不明确。该文主要围绕EMS术后GnRH-a治疗的必要性及其存在的问题,黑升麻制剂的作用机制与功能,黑升麻用于缓解EMS患者术后使用GnRH-a治疗出现的类围绝经期症状的可能性及可能存在的问题进行概述。
Endometriosis （ EMS） is one of the most common gynecological diseases in clinics , and the postoperative recurrence has always plagued clinicians .Usage of gonadotropin releasing hormone agonist （ GnRH-a） is very important for reducing EMS recurrence , and it has become the most commonly used method for preventing EMS recurrence .However , perimenopausal symptoms induced by GnRH-a usage seriously affect patients’ life quality, and some patients terminate the treatment because of it .Although add-back therapy is a very good solution for menopausal symptoms , long-term use of hormone may lead to hormone-dependent disease risk .It is still not clear whether black cohosh preparations , as a kind of plant extracts , can be a better antagonism of menopausal symptoms caused by GnRH-a administration and avoid the risk of hormone add-back therapy .This paper will mainly focus on the necessity and existing problems of post-operative GnRH-a treatment for EMS patients , mechanism and functions of black cohosh preparations , possibility and the problems of using black cohosh for remission of perimenopausal symptoms induced by postoperative GnRH-a administration in EMS patients .
出处
《中国妇幼健康研究》
2014年第2期344-347,共4页
Chinese Journal of Woman and Child Health Research
