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UMOD基因启动子区单核苷酸多态性与慢性肾脏病患者肾存活率的关系 被引量：2

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摘要 尿调蛋白由uromodulin（UMOD）基因编码，在肾脏特异性表达，与慢性肾脏病（CKD）的发生与进展相关^[1]。2009年欧洲全基因组的研究结果显示，UMOD基因启动子区单核苷酸多态性（SNP）与CKD的发生和肾小球滤过率（eGFR）相关^[2-3]。目前有关UMOD基因启动子区的SNP与CKD患者肾脏生存预后关系的研究较少。本研究探讨了UMOD启动子区SNP与CKD患者5年肾脏生存预后的关系。
作者 徐金升 白亚玲 张文博 张胜雷 张俊霞 崔立文
机构地区 河北医科大学第四医院肾内科
出处 《中华肾脏病杂志》 CAS CSCD 北大核心 2014年第5期391-392,共2页 Chinese Journal of Nephrology
基金 河北省自然科学基金（H2012206157）
关键词 基因启动子区 单核苷酸多态性 慢性肾脏病 肾存活率 患者 肾小球滤过率 生存预后 特异性表达
分类号 R692 [医药卫生—泌尿科学]
  • 相关文献

参考文献9

  • 1Prajezer S, Heidenreich U, Pfaller W, et al. Evidence for a role of uromodulin in chronic kidney disease progression[J]. Nephrol Dial Transplant, 2010, 25: 1896-1903.
  • 2Kottgen A, Glazer NL, Dehghan A, et al. Multiple loci associated with indices of renal function and chronic kidney disease[J]. Nat Genet, 2009, 41: 712-717.
  • 3Kongen A, Pattaro C, Boger CA, et al. New loci associated with kidney function and chronie kidney disease[J].Nat Genet, 2010, 42: 376-384.
  • 4Masson I, Flamant M, Maillard N, et al. MDRD versus CKD- EPI equation to estimate ghnnerular filtration rate in kidney transplant recipients[j]. Transplantation, 2013, 95: 1211-1217.
  • 5Padmanabhan S, Melander O, Johnson T, et al. Genome-wide association study of blood pressure extremes identifies variant near UMOD associated with hypertension[J]. PLoS Genet, 2010, 6:el001177.
  • 6Gudbjartsson DF. Holm H, lndridason OS, et al. Association of variants at UMOD with chrnnic kidney disease and kidney stones -role of age and cnmorbid diseases[J]. PLoS Genet, 2010, 6: e1001039.
  • 7Ahluwalia TS, Lindholm E, Groop L, et al. Uromodulin gene variant is associated with type 2 diabetic nephropathy[J]. J Hypertens, 201 L, 29:1731-1734.
  • 8张路霞,左力,徐国宾,王芳,王淑玉,王梅,吕继成,张军茹,刘力生,王海燕.北京市石景山地区中老年人群中慢性肾脏病的流行病学研究[J].中华肾脏病杂志,2006,22(2):67-71. 被引量：370
  • 9Dalrymple LS, Katz R, Kestenbaum B, et al. Chronic kidney disease and the risk of end-stage renal disease versus death[J]. J Gen Intern Med, 2011, 26: 379-385.

二级参考文献15

  • 1张路霞,王梅,王海燕.慢性肾脏病的流行病学研究[J].中华肾脏病杂志,2005,21(7):425-428. 被引量：69
  • 2Xue JL,Ma JZ,Louis TA,et al.Forecast of the number of patients with end-stage renal disease in the United States to the year 2010.J Am Soc Nephrol,2001,12:2753-2758.
  • 3Coresh J,Astor BC,Green T,et al.Prevalence of Chronic Kidney Disease and Decreased Kidney Function in the Adult US Population:Third National Health and Nutrition Examination Survey.Am J Kidney Dis,2003,41:1-12.
  • 4Chobanian AV,Bakris GL,Black HR,et al.The Seventh Report of the Joint National Committee on prevention,detection,evaluation and treatment of high blood pressure.JAMA,2003,21:2560-2572.
  • 5Anonymous.KDOQI clinical practice guidelines for chronic kidney disease:evaluation,classification,and stratification.Kidney Disease Outcome Quality Initiative.Am J Kidney Dis,2002,39 Suppl 2:S1-S246.
  • 6Chadban SJ,Briganti EM,Kerr PG,et al.Prevalence of kidney damage in Australian adults:the AusDiab kidney study.J Am Soc Nephrol,2003,14:S131-S138.
  • 7Garg AX,Kiberd BA,Clark WF,et al.Albuminuria and renal insufficiency prevalence guides population screening:results form the NHANESⅢ.Kidney Int,2002,61:2165-2175.
  • 8Ramirez SP,Mcclellan W,Port FK,et al.Risk factors for proteinuria in a large,multiracial,southeast Asian population.J Am Soc Nephrol,2002,13:1907-1917.
  • 9Levey AS,Eckardt KU,Tsukamoto Y,et al.Definition and classification of chronic kidney disease:a position statement from Kidney Disease:Improving Global Outcomes (KDIGO).Kidney Int,2005,67:2089-2100.
  • 10Zuo L,Ma YCH,Wang M,et al.Application of glomerular giltration rate estimating euqtions in Chinese patients with chronic kidney disease.Am J Kidney Dis,2005,45:463-472.

共引文献369

同被引文献10

引证文献2

二级引证文献18

中华肾脏病杂志
2014年 第5期

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