摘要
胃癌的发生发展是多因素共同作用的结果,包括环境、生物和遗传因素等,促炎因子以及抗炎因子起着重要的作用。越来越多的研究报道了炎性因子与胃癌易感性存在着重要的联系。相关炎症因子以多种途径促进胃癌的进展,包括直接激活NF-κB刺激肿瘤细胞、上调黏附因子及促进肿瘤周围血管再生,以上途径还可抑制机体免疫,促使肿瘤细胞进展和转移。目前的研究已经发现了许多炎症因子在胃癌的发生发展中起到了重要作用。
The occurrence and development of gastric cancer is the results of many factors,including environmental, biological and genetic factors. Pro-inflammatory cytokines and anti-inflammatory cy- tokines play an important roles in these processes. More and more studies report that there were im- portant links between inflammatory cytokines and susceptibility to gastric cancer. Inflammatory fac- tors promoted the progress of gastric cancer in a variety of ways, including direct activation of NF-κB stimulate cancer cells, increasing adhesion molecules and promoting the regeneration of blood vessels around the tumor. These pathways also inhibite the immunity,and cause the progression and metas- tasis of tumor cells. The current studies have found that many inflammatory cytokines play an impor- tant role in the occurrence and development of gastric cancer.
出处
《中国肿瘤》
CAS
2014年第5期399-402,共4页
China Cancer
关键词
炎症因子
胃癌
肿瘤进展
inflammatory factors
gastric cancer
progress
