摘要
目的观察前列地尔和氯沙坦联合治疗早期糖尿病肾病(DN)的临床疗效。方法 100例早期DN患者分为观察组51例和对照组49例,对照组患者给予前列地尔注射液10μg,加入100 mL生理盐水中静脉滴注,每日1次;观察组患者在对照组治疗的基础上给予氯沙坦钾片50 mg口服,每日1次;治疗4周后评定疗效,观察2组患者治疗前后的血尿素氮(BUN)、血肌酐(SCr)、24 h尿蛋白定量(UP)、总胆固醇(TC)、三酰甘油(TG)、舒张压(DBP)和收缩压(SBP)水平。结果治疗前2组患者BUN、SCr、24 h UP、TC、TG、SBP及DBP水平比较差异均无统计学意义(P>0.05);治疗后2组患者BUN、SCr及24 h UP水平均显著低于治疗前,差异有统计学意义(P<0.05);治疗后观察组患者SCr和24 h UP水平均显著低于对照组,差异有统计学意义(P<0.05);但2组患者BUN水平比较差异无统计学意义(P>0.05)。观察组患者治疗后TC、TG、SBP及DBP水平显著低于治疗前,差异有统计学意义(P<0.05)。对照组患者治疗后TC、TG及DBP水平显著低于治疗前,差异有统计学意义(P<0.05);对照组患者治疗前后SBP比较差异无统计学意义(P>0.05)。治疗后观察组患者TC和TG水平显著低于对照组,差异有统计学意义(P<0.05)。观察组患者治疗总有效率显著高于对照组,差异有统计学意义(P<0.05)。结论前列地尔和氯沙坦联合治疗早期DN的临床疗效确切,能够降低尿蛋白,改善肾功能,有效保护肾脏。
Objective To observe the clinical effect of alprostadil combined with losartan in treatment of early diabetic nephropathy（DN）. Methods One hundred patients with early DN were divided into observation group （n = 51 ） and control group（ n = 49 ）. The patients in control group were treated with alprostadil injection 10 μg and normal saline 100 mL by inter- venous drop infusion, once a day. Based on this, the patients in observation group were treated with losartan potassium tablet 50 mg orally, once a day. Four weeks after treatment, the curative effect was evaluated. The levels of blood urea nitrogen （ BUN ）, serum creatinine （ SCr）, urine protein （UP） amount in 24 hours, total cholesterol （ TC ）, triacylglycerol （ TG）, diastolic blood pressure（DBP） and systolic blood pressure（SBP） were observed in the two groups. Results There was no significant difference in the levels of BUN, SCr,24 h UP, TC, TG, SBP and DBP between the two groups before treatment（P 〉 0.05 ）. The levels of BUN, SCr and 24 h UP after treatment were significantly lower than those before treatment in the two groups （ P 〈 0. 05 ）. After treatment, the levels of SCr and 24 h UP in observation group were significantly lower than those in control group （ P 〈 0.05 ） ,but there was no significant difference in BUN level between the two groups （ P 〉 0.05 ）. The levels of TC,TG, SBP and DBP after treatment were significantly lower than those before treatment in observation group（ P 〈 0.05 ）. The levels of TC, TG and DBP after treatment were significantly lower than those before treatment in control group（ P 〈 0.05 ）. There was no significant difference in SBP level beibre and after treatment in control group（ P 〉 0.05 ）. The levels of TC and TG in observa- tion group were significantly lower than those in control group（ P 〈 0.05 ）. The total effective rate in observation group was sig- nificantly higher than that in control group （ P 〈 0.05 ）. Conclusion Alprostadil combined with losartan for treating early DN can obtain good clinical effect, reduce UP, improve renal function, and protect the kidney.
出处
《新乡医学院学报》
CAS
2014年第5期359-361,共3页
Journal of Xinxiang Medical University
关键词
糖尿病肾病
前列地尔
氯沙坦
diabetic nephropathy
alprostadil
losartan
