摘要
急性心肌梗死(AMI)相关血管血运重建治疗可显著降低患者并发症发生率和病死率,提高生活质量,但AMI相关冠状动脉血运重建后一年内心血管病事件发生率仍较高,现代医学对血运重建后的系统炎症反应、心肌组织无复流、再灌注损伤、血管内皮功能障碍等病理环节尚缺乏真正理想的对策。中药及其复方药效成分极其复杂,作用环节的靶向性虽不如化学药物明确,但多作用环节的综合效应有不可替代的优势。因此,在现代医学基础上,结合传统医学,系统研究中药、复方不同有效成分及其相互组合干预AMI血运重建后多个病理环节的机理,有望为改善AMI的二级预防效果提供新的安全有效的干预模式。
The revascularization of acute myocardial infarction （AMI） can obviously reduce the complications and mortality and improve quality of life. But the incidence of cardiovascular disease is still around 18% within one year after revascularization of AMI. The countermeasures to prevent systemic inflammation, myocardial no-reflow, reperfusion injury and vascular endothelial dysfunction after revaseularization of AMI are still lacking. The effective components of TCM medicinal and compound recipes are extremely complex, but their combined efficacy is still irreplaceable. Therefore, TCM medicinal and compound recipes are expected to improve the secondary prevention of AMI and provide a new, safe and effective intervention model.
出处
《中医杂志》
CSCD
北大核心
2014年第10期832-834,共3页
Journal of Traditional Chinese Medicine
基金
国家自然科学基金资助项目(81030063
81303150)
"重大新药创制"科技重大专项资助项目(2009ZX09502-031)
关键词
急性心肌梗死
血运重建
靶向治疗
acute myocardial infarction
revascularization
targeted therapy
