摘要
目的评价血清肿瘤标志物细胞质胸苷激酶也称为胸苷激酶1(thymidiue kinase 1,TK1)、癌胚抗原(CEA)、糖蛋白抗原19-9(CA19-9)、糖蛋白抗原72-4(CA72-4)及糖蛋白抗原242(CA242)联合检测对胃癌诊断价值。方法采用免疫印迹发光法分别检测45例胃癌患者、40例良性胃病患者以及40例健康人血清中TK1、CEA、CA19-9、CA72-4和CA242的水平,比较三组间的差异。结果胃癌组患者血清中TK1、CEA、CA19-9、CA72-4和CA242的阳性率均显著高于良性胃病组及对照组(P<0.05)。5项标志物联合检测的敏感性为82.1%,与单项检测相比差异有显著性(P<0.05)。结论 TK1、CEA、CA19-9、CA72-4和CA242对胃癌具有较高的辅助诊断价值,5项标志物联合检测有助于提高胃癌诊断的敏感性。
Abstract： Objective To evaluate the diagnostic value of combined detection with TK1, CEA, CA19-9, CA72-4 and CA242 for gastric cancer. Methods The serum TK1, CEA, CA19-9, CA72-4 and CA242 levels in 45 patients with gastric cancer,40 patients with benign gastric diseases and 40 healthy controls were measured with ELISA method. Results The positive rates of TK1, CEA, CA19-9, CA72-4 and CA242 in patients with gastric cancer were obviously higher than those in the group with benign gastric diseases and in the control group （ P 〈 0.05 ）. Moreover, the sensitivity of the combined detections including the five tumor markers were higher than those of the respective. Conclusions The serum TK1, CEA, CA19-9, CA72-4 and CA242 levels are very valuable in diagnosis of gastric cancer. The combined detection of five tumor markers can promote the sensitivity for the diagnosis of gastric cancer.
出处
《安徽医药》
CAS
2014年第4期684-686,共3页
Anhui Medical and Pharmaceutical Journal
