1O'Garra A,Arai N.The molecular basis of T helper I and T helper 2cell differentiation[J].Trends Cell Biol,2000,10(12):542-550.
2W-P Zheng,R.A.Flavell.The transcription factor GATA-3 is necessary and sufficient for Th2 cytokine gene expres- sion in CD4 T cells[J].Cell,1997,89(4):587-596.
3Fontenot JD,Gavin MA,Rudensky AY.Foxp3 programs the development and function of CD4+ CD25+ regulatory T cells[J].Nat Immunol,2003,4(4):330-336.
4Murphy CA,Langrish CL,Chen Y,et al.Divergent pro-and antiinflammatory roles for IL-23 and IL-12 in joint auto- immune inflammation[J].J exp Med,2003,198(12):1951-1957.
5Harrington LE,Hatton RD, Mangan PR,et al.Interleukin 17-producing CD4+ effector T cells develop via alineage distinct from the T helper type 1 and 2 lineages[J].Nat Im- munol,2005,6(11):1123-1132.
6Langrish CL,Chen Y,Blumenschein WM,et al.IL-23 drives a pathogenic T cell population that induces autoim- mune inflammation[J].J Exp Med,2005,201(2):233-240.
7Mangan PR,Harrington LE,O'Quinn DB,et al.Transform- ing growth factor-beta induces development of the T (H)17 lineage[J].Nature,2006,441(7090):231-234.
8Veldhoen M,Hocking RJ,Atkins CJ,et al.TGFbeta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells[J].Immu- nity,2006,24(2):179-189.
9Kimora A,Naka T,Kishimoto T,et al.IL-6-dependent and-independent pathways in the development of inter- leukin 17-producing T helper cells[J].Proe Natl Acad Sci USA,2007,104(29):12099-12104.
10Nurieva R,Yang XO,Martinez G,et a,Essential autoerine regulation by IL-21 in the generation of inflammatory T cells[J].Nature,2007,448(7152):480-483.
3Liver Failure and Artificial Liver Group, Chinese Society of Infectious Diseases, Chinese Medical Association.肝衰竭诊疗指南[J].中华肝脏病杂志,2006,14(9):643-646. 被引量：831
6[1]Trinehiefi G.Intedeukin-12:a proinflammatory eytokine with immunoregulatory functions that bridge innate resistance and antigen-specifie adaptive immunity[J].Annu Rev lmmunol,1995,13(5):251-276.
7[2]Infante-Duaete C,Horton HF.Byrne MC,et al.Microbial lipopeptides induce the production of IL-17 in Th cells[J].J lmmunol,2000,165(11):6107-6115.
8[3]Langrish CL,Chen Y,Blumenschein WM,et al.IL-23 drives a pathogenic T cell population that induces autoimmune inflammation[J].J Exp Med,2005,201(2):233-240.
9[4]Park H,Li Z,Yang XO,et al.A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17[J].Nat lmmunol,2005,6(11):1133-1141.
10[6]Bettelli E,Carrier Y,Gao W,et al.Reciprocal developmental pathways for the generation of pathogenic effector TH17 and rogulatory T cells[J].Nature,2006,441(7090):235-238.
