摘要
目的:观察康艾注射液辅助化疗治疗晚期食管癌肝转移患者的临床疗效。方法:将73例晚期食管癌肝转移患者分为观察组37例和对照组36例;对照组采用常规化疗方法,观察组在对照组治疗基础上静脉滴注康艾注射液。比较2组患者近期疗效以及血常规、肝、肾功能的变化。结果:总有效率观察组48.65%,对照组30.56%,2组比较,差异有显著性意义(P<0.05);2组患者治疗前后白细胞和谷丙转氨酶比较,差异均无显著性意义(P>0.05)。观察组治疗后血红蛋白升高,与治疗前比较,差异有显著性意义(P<0.05),明显高于对照组(P<0.05)。2组患者治疗前后尿素氮(BUN)、血肌酐(SCr)、内生肌酐清除率(CCr)水平比较,差异均无显著性意义(P>0.05),2组治疗后比较,差异也无显著性意义(P>0.05)。结论:康艾注射液能够提高晚期食管癌肝转移患者的近期临床疗效,提高患者血红蛋白的水平,对患者的肝功能和肾功能具有保护作用,使用安全,值得临床推广。
Objective：To obs erve the clinical effect of Kang＇ai Injection adjuvant chemotherapy for advanced es ophageal cancer with liver metas tas is. Methods： Seventy- three cas es of advanced es ophageal cancer with liver metas tas is were divided into obs ervation group（37 cas es） and control group（36 cas es）. The control group was treated with routine chemotherapy,and the obs ervation group was treated with Kang＇ai Injection combined with chemotherapy. The s hort- term clinical effect was evaluated after treatment, and the changes of blood routine, liver and renal function were obs erved. Results：The total effective rate was 48.65% in the obs ervation group,and was 30.56% in the control group,the difference being s ignificant（P〈0.05）. The differences of white blood cells and aminotrans feras e,as well as s erum creatinine（SCr）,blood urea nitrogen（BUG）,and endogenous creatinine clearance rate（CCr） in both groups were ins ignificant（P〈0.05） before and after treatment,and the differences of BUN,SCr,and CCr in the two groups after treatment were als o ins ignificant（P〈0.05）. The level of hemoglobin in the obs ervation group was increas ed after treatment（P〈0.05 compared with before treatment）,and the increas e was s uperior to that in the control group after treatment（P〈0.05）. Conclusion： Kang＇ai Injection can improve the s hort- term efficacy of chemotherapy for advanced es ophageal cancer with liver metas tas is by increas ing hemoglobin, and protecting the liver function and renal function of patients,and is worth of clinical promotion.
出处
《新中医》
CAS
2014年第6期164-166,共3页
New Chinese Medicine
关键词
食管癌肝转移
康艾注射液
肾功能
血常规
Es ophageal cancer with liver metas tas is Kang＇ai Injection Renal function Blood routine
