摘要
目的:研究没药挥发油对布洛芬体外透皮吸收影响,为布洛芬寻找天然透皮促渗剂及制备布洛芬的外用制剂提供参考。方法:以布洛芬为模型药物,鼠皮为透皮介质,采用高效液相色谱法测定布洛芬的含量和经皮渗透试验,考察没药挥发油对布洛芬透皮吸收的影响。结果:无没药挥发油与含1%,2%,3%没药挥发油对布洛芬体外透皮吸收12h的累积渗透量分别为(0.427 05±0.069 82),(0.315 04±0.032 24),(0.230 50±0.031 14),(0.181 34±0.053 70)mg·cm-2和透皮吸收速率Jss分别为(0.031 4±0.005 7),(0.020 8±0.002 8),(0.017 2±0.001 6),(0.013 9±0.003 4)mg·(cm2·h)-1。结论:没药挥发油对布洛芬未表现出促透作用,甚至抑制布洛芬的体外透皮吸收,且抑制作用随着没药挥发油的浓度增加而增强。
To study the transdermal characteristics of myrrh essential oil and its percutaneous penetration enhancement for ibuprofen. Methods： The content of ibuprofen was determined by HPLC. Ibuprofen was used as the model drug and mouse skin was used as the permeation barrier in vitro. The transdermal properties of myrrh essential oil and its effect on percutaneous absorption of ibuprofen were investigated using Franz diffusion ceils. Results： Without myrrh essential oil or with 1%, 2% and 3% myrrh essential oil, the cumulative transdermal penetration amount in 12h of ibuprofen in vitro was （0.427 05 ±0.069 82）, （0.315 04±0.032 24）, （0.230 50 ＋0.031 14） and （0. 181 34±0.053 70） mg·cm^-2, withJss of（0.031 4±0.005 7）, （0.020 8±0.002 8）, （0.017 2±0.001 6） and （0.013 9±0.003 4） mg·（cm^2 h）^-1, respectively. Conclusion： Myrrh essential oil shows no transdermal en-hancement for ibuprofen in vitro, to the contrary, it shows inhibitory effect with positive correlation to the concentration.
出处
《中国药师》
CAS
2014年第5期740-742,共3页
China Pharmacist
基金
广东省教育厅2013年高等教育教学改革重点项目(编号:2013113-209)
广东省大学生创新创业训练计划项目(编号:1057112067)
关键词
没药挥发油
布洛芬
透皮吸收
Myrrh essential oil
Ibuprofen
Transdermal absorption
