摘要
除幽门螺杆菌之外,胃黏膜内还定居着大量细菌,占主导地位的是厚壁菌门、变形菌门、拟杆菌门、放线菌门和梭杆菌门。幽门螺杆菌和胃黏膜菌群之间可通过竞争营养和空间、扰乱抑菌肽的分泌以及改变宿主胃生理环境等直接或间接相互影响。本研究总结了胃内正常菌群的组成特征,分析了胃黏膜菌群与幽门螺杆菌之间的相互关系及其潜在机制,并进一步探讨了胃黏膜菌群对幽门螺杆菌相关胃部疾病的影响,有利于深入理解慢性胃病的发病机制,为疾病预防及治疗提供理论依据。
In addition to Helicobacter pylori（ H. pylori）, there are a large number of bacteria inhabiting the gastric mucosa. Firmicutes, Proteobacteria, Bacteroidetes, Actinobacteria and Fusobacteria dominant the gastric microbiota. H. pylori and gastric microbiota can influence each other through competing for living space and nutrition, disturbing the secretion of antimicrobial peptides, even altering physiological state of the host stomach. This paper summarizes the characteristics of the normal gastric microbiota, analyzes the interactions and potential mechanisms between gastric microbiota and H. pylori, and discusses the impact of gastric microbiota on H. pylori-related diseases. This would benefit for understanding of the pathogenesis of gastric diseases, providing theoretical basis for the prevention and treatment of those diseases.
出处
《中国微生态学杂志》
CAS
CSCD
2014年第5期609-613,共5页
Chinese Journal of Microecology
关键词
幽门螺杆菌
胃黏膜菌群
胃癌
Helicobacter pylori
Gastric microbiota
Gastric cancer
