摘要
目的:观察长春瑞滨(NVB)联合吉西他滨(GEM)治疗复发或转移性乳腺癌的疗效及安全性。方法:对符合标准的34例复发或转移性乳腺癌患者均给予NVB 25 mg/m2静滴,第1、8天;GEM 1 000 mg/m2静滴,第1、8天,21 d为1周期,至少2个周期后评价疗效,平均完成3.4个周期。结果:34例患者中,完全缓解(CR)3例,部分缓解(PR)12例,总有效率44.1%,中位TTP 7.4个月。结论:NVB联合GEM治疗复发转移性乳腺癌有一定疗效,其毒副作用患者可以耐受,是复发或转移性乳腺癌较为理想的治疗方案。
Objective ： To study the therapeutic effect and safety of vinorelbine combined with gemcitabine in the treatment of recurrent or metastatic breast cancer. Methods ： 34 patients with recurrent or metastatic breast cancer were enrolled into the trial. Vinorelbine and gemcitabine were given at a dose of 25 mg/m2 and 1 000 mg/m2 respectively by intravenous injection at day 1, 8 respectively,repeated every 21 days. All patients received over 2 cycles of chemotherapy,with an average of 3.4 cycles. Results ： Among these 34 patients, the overall response rate was 44.1% with 3 CR, 12 PR. The median TTP was 7.4 months. Conclusion： The combination of vinorelbine and gemeitabine in the treatment of recurrent or metastatic breast cancer was effective and the toxicities were tolerable. This regimen was ideal for patients with recurrent or metastatic breast cancer.
出处
《河南医学研究》
CAS
2014年第4期109-111,共3页
Henan Medical Research
关键词
长春瑞滨
吉西他滨
复发或转移性乳腺癌
化疗
vinorelbine
gemcitabine
recurrent or metastatic breast cancer
chemotherapy
